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Altmaier, E. ; Kastenmüller, G. ; Römisch-Margl, W. ; Thorand, B. ; Weinberger, K.M.* ; Illig, T. ; Adamski, J. ; Döring, A. ; Suhre, K.

Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics.

Eur. J. Epidemiol. 26, 145-156 (2011)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Nutrition plays an important role in human metabolism and health. However, it is unclear in how far self-reported nutrition intake reflects de facto differences in body metabolite composition. To investigate this question on an epidemiological scale we conducted a metabolomics study analyzing the association of self-reported nutrition habits with 363 metabolites quantified in blood serum of 284 male participants of the KORA population study, aged between 55 and 79 years. Using data from an 18-item food frequency questionnaire, the consumption of 18 different food groups as well as four derived nutrition indices summarizing these food groups by their nutrient content were analyzed for association with the measured metabolites. The self-reported nutrition intake index "polyunsaturated fatty acids" associates with a decrease in saturation of the fatty acid chains of glycero-phosphatidylcholines analyzed in serum samples. Using a principal component analysis dietary patterns highly associating with serum metabolite concentrations could be identified. The first principal component, which was interpreted as a healthy nutrition lifestyle, associates with a decrease in the degree of saturation of the fatty acid moieties of different glycero-phosphatidylcholines. In summary, this analysis shows that on a population level metabolomics provides the possibility to link self-reported nutrition habits to changes in human metabolic profiles and that the associating metabolites reflect the self-reported nutritional intake. Moreover, we could show that the strength of association increases when composed nutrition indices are used. Metabolomics may, thus, facilitate evaluating questionnaires and improving future questionnaire-based epidemiological studies on human health.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dietary pattern; Metabolomics; Mass spectrometry; Nutrition habits; Food questionnaires; Epidemiology
Sprache englisch
Veröffentlichungsjahr 2011
Prepublished im Jahr 2010
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 0393-2990
e-ISSN 1573-7284
Zeitschrift European Journal of Epidemiology
Quellenangaben Band: 26, Heft: 2, Seiten: 145-156 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Bioinformatics and Systems Biology (IBIS)
Institute of Epidemiology (EPI)
Molekulare Endokrinologie und Metabolismus (MEM)
Research Unit Molecular Epidemiology (AME)
POF Topic(s) 30505 - New Technologies for Biomedical Discoveries

30201 - Metabolic Health
30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Enabling and Novel Technologies

Genetics and Epidemiology
PSP-Element(e) G-503700-001
G-503900-004
G-505600-001
G-504000-002
G-504200-003
G-504090-001
PubMed ID 21116839
DOI 10.1007/s10654-010-9524-7
Scopus ID 79954440018
Erfassungsdatum 2010-12-31
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