PuSH - Publikationsserver des Helmholtz Zentrums München: Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Leibold, E. ; Schwarz, L.R.

Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes.

Carcinogenesis 14, 2127-2129 (1993)

Verlagsversion

DOI

PMC

	Closed

Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

Abstract
Metriken
Zusatzinfos

Gap junctional intercellular communication (IC) was studied in γ-glutamyltranspeptidase (γ-GT)-positive and -negative hepatocytes isolated from carcinogen-treated rats. Putative preneoplastic γ-GT-positive hepatocytes were visualized in monolayer cultures by indirect immunofluorescence using anti-γ-GT-antibodies. IC was evaluated by studying dye coupling of the cells. γ-GT-positive hepatocytes showed a significantly lower dye coupling than did γ-GT-negative liver cells. Spread of the dye Lucifer Yellow CH to neighboring cells was decreased further by the tumor-promoting chemical phenobarbital in both cell types in vitro. Also treatment in vivo with the barbiturate significantly reduced dye coupling of hepatocytes. The findings suggest that as a result of their decreased ability to communicate, preneoplastic hepatocytes may escape from growth control and differentiation signals given out by surrounding 'normal' cells.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

0.000