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Pfab, F. ; Valet, M.* ; Tölle, T.* ; Behrendt, H. ; Ring, J. ; Darsow, U.

Recent progress in unraveling central nervous system processing of itch sensation.

World Allergy Organiz. J. 10, 168-173 (2008)
Verlagsversion DOI PMC
Open Access Gold
Itch is the major symptom of many allergic or inflammatory skin diseases, yet it is still difficult to measure objectively. This article shows and updates the development and approaches of central nervous system investigation of itch.Human neuroimaging studies on the physiology and pathophysiology of itch sensation have been hampered by the lack of a reproducible "on-off" stimulus. Short-term alternating temperature modulation of histamine-induced itch has recently been shown to provide on-off characteristics.Recent studies with functional magnetic resonance imaging demonstrate that itch sensation in healthy volunteers is processed by a network of brain regions contributing to the encoding of sensory, emotional, attentional, evaluative, and motivational aspects of itch.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter itch; cerebral processing; neuroimaging; histamine
Sprache englisch
Veröffentlichungsjahr 2008
HGF-Berichtsjahr 0
e-ISSN 1939-4551
Zeitschrift World Allergy Organization Journal
Quellenangaben Band: 10, Heft: , Seiten: 168-173 Artikelnummer: , Supplement: ,
Verlag BioMed Central
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
PSP-Element(e) G-521200-001
FE 73991
PubMed ID 23282675
DOI 10.1097/WOX.0b013e318187ff70
Erfassungsdatum 2008-10-30
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