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Ziegler, I. ; Hültner, L.

Tetrahydro-6-biopterin is associated with tetrahydro-7-biopterin in primary murine mast cells.

FEBS Lett. 307, 147-150 (1992)
Verlagsversion DOI PMC
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Murine bone marrow-derived mast cells proliferate in response to interleukin 3. In addition to 6-biopterin, 7-biopterin was identified in these cells by HPLC analysis of iodine oxidized extracts and by alkaline permanganate oxidation to the 6- and 7-carboxylic acids. 7-Biopterin comprised 31.9 (±7.7)% of the total biopterin. It was absent in cells which were grown with of L-p-chlorophenylalanine, an inhibitor of tryptophan 5-monooxygenase. Both 6- and 7-biopterin were present in the cell as their tetrahydro forms. From these data we conclude that 7-biopterin, in contrast to e.g. brain tissue, regularly occurs as a normal metabolite in primary mast cells and that it is generated during hydroxylation of tryptophan.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter 6-biopterin ; 7-biopt Erin ; Mast Cell ; Tetrahydro-6-biopterin ; Tetrahydro-7-biopterin ; Tryptophan 5-mono-oxygenase
Sprache
Veröffentlichungsjahr 1992
HGF-Berichtsjahr 1992
ISSN (print) / ISBN 0014-5793
e-ISSN 1873-3468
Zeitschrift FEBS Letters
Quellenangaben Band: 307, Heft: 2, Seiten: 147-150 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501400-005
DOI 10.1016/0014-5793(92)80755-6
Scopus ID 0026725401
PubMed ID 1644167
Erfassungsdatum 1992-07-28
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