PuSH - Publikationsserver des Helmholtz Zentrums München: Effect of irradiated dib-cAMP on the tonic and phasic activity of human myometrium.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Schachinger, L. ; Srivastava, A.K. ; Schippel, C. ; Klöter, H.

Effect of irradiated dib-cAMP on the tonic and phasic activity of human myometrium.

Strahlenther. Onkol. 159, 358-365 (1983)

DOI

PMC

Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

Abstract
Metriken
Zusatzinfos

Cyclic AMP, used as dibutyryl derivative for better permeability, has a relaxing effect on smooth muscle preparations from human uterine tissue (surgical material). The observed decrease of tonus and frequency depends on the concentration applied, shown in the range between 50 and 300 μM. cAMP looses its physiological activity by irradiation in vitro; in addition an inhibitory action of the irradiation products on uterine tissue could be proved. From the data of the Lineweaver-Burk plots, showing the competition between non-irradiated and irradiated cAMP, a ten- to twentyfold higher affinity of the irradiation products to the receptor compared to that of this transmitter could be calculated. The results show that preparations of human origin with β-receptors behave similarly to animal tissues with β-receptors. They are further discussed with respect to a better understanding of dose-response curves for chemical and physiological inactivation.

Impact Factor

Scopus SNIP

Altmetric

0.000