PuSH - Publikationsserver des Helmholtz Zentrums München: Scheduled and unscheduled DNA synthesis in chick embryo liver following x-irradiation and treatment with DNA repair inhibitors <em>in vivo</em>.

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Stammberger, I.* ; Schmahl, W.G. ; Tempel, K.H.*

Scheduled and unscheduled DNA synthesis in chick embryo liver following x-irradiation and treatment with DNA repair inhibitors in vivo.

Int. J. Radiat. Biol. 56, 325-333 (1989)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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Three hours following X-irradiation of chick embryos with doses of 4 and 8 Gy the in vitro incorporation of tritiated thymidine ([3H]dT) into DNA (scheduled DNA synthesis, ss) of hepatocytes was reduced to about one-third. Within 24 h after the exposure, ss returned to control values. The return of ss to a normal rate could be strongly inhibited by 2'3'dideoxythymidine (ddT), and to a lesser extent by 1-βd-arabinofuranosylcytosine (araC). In strong contrast to ss, the hydroxyurea (hu)-resistant [3H]dT incorporation (unscheduled DNA synthesis, us) showed a highly significant increase 24 h after treatment of the embryos with araC and/or X-irradiation. Autoradiographic studies revealed no change of total [3H]dT labelling frequency in the whole chick embryo liver 24 h after treatment with araC and/or X-irradiation, but a persistent depression of ss and a simultaneous increase of us. The histological discrimination between affected and non-affected areas argue for a stimulation of DNA synthesis as an antecedent of subsequent mitosis and reparative proliferation adjacent to cell necrosis. It is suggested that the fast recovery of ss in the 12-15-day-old chick embryo is due to an efficient DNA repair system for which DNA polymerase β is important. The increase of hu-resistance may be an expression of an aberrant DNA synthesis.

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