PuSH - Publikationsserver des Helmholtz Zentrums München: Proliferative activity of bone marrow cells in acute lymphocytic leukemia: Variation of cell kinetics with clinical manifestation.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Lau, B. ; Dörmér, P.G. ; Haas, R.J.* ; Janka, G.E.*

Proliferative activity of bone marrow cells in acute lymphocytic leukemia: Variation of cell kinetics with clinical manifestation.

Leuk. Res. 2, 241-245 (1978)

DOI

Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

Abstract
Metriken
Zusatzinfos

Cell-kinetic investigations were carried out in a 15-year-old girl, initially presenting bicytopenia and changing gradually to cALL. At three instances during this transitional stage of the disease, the proliferation kinetics were studied in the cALL blast cell population as well as in erythroblasts and myelocytes. The percentage of blasts in the bone-marrow was 39, 42 and 70%, respectively. The DNA synthesis time in individual cells was measured by using the technique of quantitative 14C-autoradiography. Parallel with the increase in the number of blast cells a shortening of their time of DNA synthesis from 28.9 to 21.6 h was observed. Concomitantly with this development the kinetic parameters of erythroblasts and myelocytes normalized from initially extended values, and the anemia improved. A mutual inhibition between normal and malignant cell growth in bone marrow at the onset of overt leukemia is discussed as a possible interpretation of the course of the disease in this case.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

0.000