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Born, R. ; Eichholtz-Wirth, H.

Effect of different physiological conditions of the action of adriamycin on Chinese hamster cells in vitro.

Br. J. Cancer 44, 241-246 (1981)
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Chronically hypoxic cells were 5 times more resistant to Adriamycin (ADR) than exponentially growing oxic cells. On reoxygenation, resistance decreased slowly to reach the ADR sensitivity of oxic cells after 24 h. With increasing pH, ADR efficiency increased more in oxic than in chronically hypoxic cells. With increasing cell density, ADR efficiency decreased linearly. The differences in ADR efficiency under the various conditions were accompanied by differences in intracellular ADR uptake. Chronically hypoxic cells incorporated 1.6 times less than oxic cells; the incorporation rate at pH 6.5 was half that at pH 7.4; and at a cell density of 5x105/bottle the intracellular uptake was 6 times that at 5x106/bottle. The observed differences in uptake of ADR were not, however, sufficient to explain the differences in cytotoxicity.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 1981
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0007-0920
e-ISSN 1532-1827
Zeitschrift British Journal of Cancer BJC
Quellenangaben Band: 44, Heft: 2, Seiten: 241-246 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Begutachtungsstatus Peer reviewed
Institut(e) Abteilung für Strahlenbiologie und Biophysik
Scopus ID 0019465470
Erfassungsdatum 1981-12-31
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