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Mellert, W.* ; Kleinschmidt, A.M.* ; Schmidt, J.* ; Festl, H.* ; Emler, S.* ; Roth, W.K.* ; Erfle, V.F.

Infection of human fibroblasts and osteoblast-like cells with HIV-1.

Aids 4, 527-535 (1990)

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Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.

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Primary human skin- and lung-derived fibroblast cell cultures and continuous human osteoblast-like and fibroblast-like cell lines were infected with different strains of HIV-1. Infection was measured at the single-cell level using the immunoperoxidase staining method to detect viral proteins. No cytopathic effects were observed in HIV-1-infected cell cultures. One continuous cell line (LC5), derived from embryonic lung, was readily infectable with HIV-1 and showed continuous production of infectious virus. Infection of LC5 cells could be blocked with anti-CD4 monoclonal antibodies. These findings indicate that fibroblasts of skin and lung, and osteogenic cells may be considered as potential target cells for HIV-1, thereby possibly contributing to the establishment of local HIV reservoirs.

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