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Luz, A. ; Murray, A.B.

Sudden outbreak of a leukemia-like lesion in female CBA mice after repeated injections of 5-azacytidine.

J. Cancer Res. Clin. Oncol. 114, 525-527 (1988)
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A total of 11 i.p. injections of 1 mg/kg 5-azacytidine given within 21 weeks induced a sudden outbreak of a leukemia-like disease in female CBA mice about 2 weeks after the last injection. The outbreak of disease was highly synchronous; 68% of animals who had survived the treatment period succumbed within a period of 5 days, 2/3 of them on a single day. The lesion had a characteristic form commonly presenting as a result of hemorrhagic effusion in the thoracic and/or abdominal cavities, associated with diffuse infiltration of lymphatic and fatty tissue by lymphoblasts. It appears that a critical combination of factors was responsible for the unexpected appearance of the lesion. Female BALB/c mice treated identically were not affected. The factors indicating that the lesion was induced by an epigenetic mechanism are discussed.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter 5-azacytidine ; Cba Mice ; Leukemia-like Lesion
Sprache englisch
Veröffentlichungsjahr 1988
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0171-5216
e-ISSN 1432-1335
Zeitschrift Journal of Cancer Research and Clinical Oncology
Quellenangaben Band: 114, Heft: 5, Seiten: 525-527 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pathology (PATH)
DOI 10.1007/BF00391506
Scopus ID 0023714413
Erfassungsdatum 1988-12-31
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