Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus.
Curr. Diab. Rep. 9, 113-118 (2009)
Autoreactive T cells play a major role in the pathogenesis of type 1 diabetes mellitus (T1DM) and are considered a major target of immunomodulatory strategies aimed at preventing or delaying the disease onset. However, the T-cell response against insulin-producing beta cells is still poorly understood. T cells potentially able to recognize and destroy beta cells are present in most individuals, but only in a few do they differentiate into pathogenic effectors. Recent and novel findings in T-cell biology on the dynamics of T-cell activation and memory maintenance are shedding new light on the general mechanisms of the T-cell response. In this article, we discuss how new discoveries about T-cell differentiation, expansion, and homeostasis could help to clarify mechanisms of autoimmunity that lead to T1DM.
Impact Factor
Scopus SNIP
Altmetric
0.000
0.590
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2009
HGF-Berichtsjahr
0
ISSN (print) / ISBN
1534-4827
e-ISSN
1539-0829
Zeitschrift
Current Diabetes Reports
Quellenangaben
Band: 9,
Heft: 2,
Seiten: 113-118
Verlag
Springer
Verlagsort
Heidelberg [u.a.]
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Pancreatic Islet Research (IPI)
PubMed ID
19323955
Erfassungsdatum
2009-12-31