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Fall, T.* ; Hägg, S.* ; Ploner, A.* ; Mägi, R.* ; Fischer, K.* ; Draisma, H.H.* ; Sarin, A.P.* ; Benyamin, B.* ; Ladenvall, C.* ; Åkerlund, M.* ; Kals, M.* ; Esko, T.* ; Nelson, C.P.* ; Kaakinen, M.* ; Huikari, V.* ; Mangino, M.* ; Meirhaeghe, A.* ; Kristiansson, K.* ; Nuotio, M.L.* ; Kobl, M. ; Grallert, H. ; Dehghan, A.* ; Kuningas, M.* ; de Vries, P.S.* ; de Bruijn, R.F.* ; Willems, S.M.* ; Heikkilä, K.* ; Silventoinen, K.* ; Pietiläinen, K.H.* ; Legry, V.* ; Giedraitis, V.* ; Goumidi, L.* ; Syvanen, A.C.* ; Strauch, K. ; Koenig, W.* ; Lichtner, P. ; Herder, C.* ; Palotie, A.* ; Menni, C.* ; Uitterlinden, A.G.* ; Kuulasmaa, K.* ; Havulinna, A.S.* ; Moreno, L.A.* ; Gonzalez-Gross, M.* ; Evans, A.* ; Tregouet, D.A.* ; Yarnell, J.W.* ; Virtamo, J.* ; Ferrieres, J.* ; Veronesi, G.* ; Perola, M.* ; Arveiler, D.* ; Brambilla, P.* ; Lind, L.* ; Kaprio, J.* ; Hofman, A.* ; Stricker, B.H.* ; van Duijn, C.M.* ; Ikram, M.A.* ; Franco, O.H.* ; Cottel, D.* ; Dallongeville, J.* ; Hall, A.S.* ; Jula, A.* ; Tobin, M.D.* ; Penninx, B.W.* ; Peters, A. ; Gieger, C. ; Samani, N.J.* ; Montgomery, G.W.* ; Whitfield, J.B.* ; Martin, N.G.* ; Groop, L.* ; Spector, T.D.* ; Magnusson, P.K.* ; Amouyel, P.* ; Boomsma, D.I.* ; Nilsson, P.M.* ; Jarvelin, M.R.* ; Lyssenko, V.* ; Metspalu, A.* ; Strachan, D.P.* ; Salomaa, V.* ; Ripatti, S.* ; Pedersen, N.L.* ; Prokopenko, I.* ; McCarthy, M.I.* ; Ingelsson, E.*

Age- and sex-specific causal effects of adiposity on cardiovascular risk factors.

Diabetes 64, 1841-1852 (2015)
Verlagsversion DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Observational studies have reported different effects of adiposity on cardiovascular risk factors across age and sex. Since cardiovascular risk factors are enriched in obese individuals, it has not been easy to dissect the effects of adiposity from those of other risk factors. We used a Mendelian randomization approach, applying a set of 32 genetic markers to estimate the causal effect of adiposity on blood pressure, glycemic indices, circulating lipid levels, and markers of inflammation and liver disease in up to 67,553 individuals. All analyses were stratified by age (cutoff 55 years of age) and sex. The genetic score was associated with BMI in both nonstratified analysis (P = 2.8 × 10(-107)) and stratified analyses (all P < 3.3 × 10(-30)). We found evidence of a causal effect of adiposity on blood pressure, and fasting levels of insulin, C-reactive protein, interleukin-6, HDL cholesterol, and triglycerides in a nonstratified analysis and in the <55-year stratum. Further, we found evidence of a smaller causal effect on total cholesterol (P for difference = 0.015) in the ≥55-year stratum than in the <55-year stratum, a finding that could be explained by biology, survival bias, or differential medication. In conclusion, this study extends previous knowledge of the effects of adiposity by providing sex- and age-specific causal estimates on cardiovascular risk factors.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Body-mass Index; C-reactive Protein; Insulin-resistance; Gender-differences; Blood-pressure; Mendelian Randomization; Association; Disease; Obesity; Adults
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Zeitschrift Diabetes
Quellenangaben Band: 64, Heft: 5, Seiten: 1841-1852 Artikelnummer: , Supplement: ,
Verlag American Diabetes Association
Verlagsort Alexandria, VA.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504100-001
G-504091-002
G-504091-004
G-500700-001
G-504000-001
PubMed ID 25712996
DOI 10.2337/db14-0988
WOS ID WOS:000353431200039
Scopus ID 84964694797
Erfassungsdatum 2015-02-27
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