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Düber, S.* ; Hafner, M.* ; Krey, M.* ; Lienenklaus, S.* ; Roy, B.* ; Hobeika, E.* ; Reth, M.* ; Buch, T.* ; Waisman, A.* ; Kretschmer, K.* ; Weiss, S.*

Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells.

Blood 114, 4960-4967 (2009)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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To study B-cell development from bone marrow (BM), we generated recombination-activating gene 1 (Rag1)-targeted mice lacking mature lymphocytes. B-cell development can be induced in such mice by B cell-specific restoration of a functional Rag1 transcription unit. Follicular and marginal zone B cells populated the spleen when Rag1 expression was permitted. Notably, the peritoneal cavity was dominated by bona fide B-1a cells, as judged by surface markers and functional properties. These BM-derived B-1a cells exhibited a polyclonal VDJ repertoire with substantial N nucleotide insertions. Nevertheless, physiologic frequencies of phosphatidylcholine-specific B cells were detected. Importantly, the BM of young and 5-month-old mice was indistinguishable with regard to the potential to generate B-1a cells.

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