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Synthetic membrane curvature-inducing DNA origami scaffolds.
Biophys. J. 106:617a (2014)
Biological membranes are dynamic cellular barriers that suffer deformation and bending. Despite huge effort in identifying the general elements involved in membrane curvature, the physical-chemical basis of curvature induction is still poorly understood. In this work, we fill this gap by engineering a minimal curvature-inducing system. Due to its exclusive nanoengineering properties, DNA origami technology will be utilized to build minimal curvature-inducing scaffoldings. This state-of-the-art technology enables the folding of long strands of DNA into nano-objects with defined shapes by using sequence-specific short DNA staples.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2014
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0006-3495
e-ISSN
1542-0086
Zeitschrift
Biophysical Journal
Quellenangaben
Band: 106,
Heft: 2,
Artikelnummer: 617a
Verlag
Elsevier
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Pancreatic Islet Research (IPI)
Erfassungsdatum
2014-12-31