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Tsuchiya, T.* ; Schwarz, P.E.* ; Bosque-Plata, L.D.* ; Geoffrey Hayes, M.* ; Dina, C.* ; Froguel, P.* ; Towers, G.W.* ; Fischer, S.* ; Temelkova-Kurktschiev, T.* ; Rietzsch, H.* ; Graessler, J.* ; Vcelák, J.* ; Palyzová, D.* ; Selisko, T.* ; Bendlová, B.* ; Schulze, J.* ; Julius, U.* ; Hanefeld, M.* ; Weedon, M.N.* ; Evans, J.C.* ; Frayling, T.M.* ; Hattersley, A.T.* ; Orho-Melander, M.* ; Groop, L.* ; Malecki, M.T.* ; Hansen, T.* ; Pedersen, O.* ; Fingerlin, T.E.* ; Boehnke, M.* ; Hanis, C.L.* ; Cox, N.J.* ; Bell, G.I.*

Association of the calpain-10 gene with type 2 diabetes in Europeans: Results of pooled and meta-analyses.

Mol. Genet. Metab. 89, 174-184 (2006)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
We conducted pooled and meta-analyses of the association of the calpain-10 gene (CAPN10) polymorphisms SNP-43, Indel-19 and SNP-63 individually and as haplotypes with type 2 diabetes (T2D) in 3237 patients and 2935 controls of European ancestry. In the pooled analyses, the common SNP-43*G allele was associated with modest but statistically significant increased risk of T2D (odds ratio (OR)=1.11 (95% confidence interval (CI), 1.02-1.20), P=0.01). Two haplotype combinations were associated with increased risk of T2D (1-2-1/1-2-1, OR=1.20 (1.03-1.41), P=0.02; and 1-1-2/1-2-1, OR=1.26 (1.01-1.59), P=0.04) and one with decreased risk (1-1-1/2-2-1, OR=0.86 (0.75-0.99), P=0.03). The meta-analysis also showed a significant effect of the 1-2-1/1-2-1 haplogenotype on risk (OR=1.25 (1.05-1.50), P=0.01). However, there was evidence for heterogeneity with respect to this effect (P=0.06). The heterogeneity appeared to be due to data sets in which the cases were selected from samples used in linkage studies of T2D. Using only the population-based case-control samples removed the heterogeneity (P=0.89) and strengthened the evidence for association with T2D in both the pooled (SNP-43*G, OR=1.19 (1.07-1.32), P=0.001; 1-2-1/1-2-1 haplogenotype, OR=1.46 (1.19-1.78), P=0.0003; 1-1-2/1-2-1 haplogenotype, OR=1.52 (1.12-2.06), P=0.007; and 1-1-1/2-2-1 haplogenotype, OR=0.83 (0.70-0.99), P=0.03) and the meta-analysis (SNP-43*G, OR=1.18 (1.05-1.32), P=0.005; 1-2-1/1-2-1 haplogenotype, OR=1.68 (1.33-2.11), P=0.00001). The pooled and meta-analyses as well as the linkage disequilibrium and haplotype diversity studies suggest a role for genetic variation in CAPN10 affecting risk of T2D in Europeans.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2006
HGF-Berichtsjahr 0
ISSN (print) / ISBN 1096-7192
e-ISSN 1096-7192
Zeitschrift Molecular Genetics and Metabolism
Quellenangaben Band: 89, Heft: 1-2, Seiten: 174-184 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502600-001
PubMed ID 16837224
DOI 10.1016/j.ymgme.2006.05.013
Erfassungsdatum 2006-12-31
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