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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
RET rearrangements in post-Chernobyl papillary thyroid carcinomas with a short latency analysed by interphase FISH.
Br. J. Cancer 94, 1472-1477 (2006)
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DOI
PMC
Tissue samples from 13 post-Chernobyl childhood thyroid tumours that occurred within a short period of time (4-8 years) after the Chernobyl accident have been investigated by interphase FISH analysis for rearrangements of RET. In all, 77% of cases showed RET/PTC rearrangements and a distinct intratumoural genetic heterogeneity. The data were compared to findings on 32 post-Chernobyl PTCs that occurred after a longer period of time (9-12 years) after the accident. In none of the cases from either group were 100% of cells positive for RET rearrangement. In addition, the pattern of RET-positive cells was different in the two groups (short vs longer latency). A significant clustering of aberrant cells could be detected in the long-latency subgroup, whereas the aberrant cells were more homogeneously distributed among the short-latency tumours. The findings suggest that oligoclonal tumour development occurs in post-Chernobyl PTCs. This pattern of different clones within the tumour appears to become more discrete in cases with longer latencies, suggesting either outgrowth of individual clones or development of later subclones with time.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Altmetric
4.115
0.000
23
Anmerkungen
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
thyroid; papillary; carcinoma; FISH; Chernobyl; tumour
Sprache
englisch
Veröffentlichungsjahr
2006
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0007-0920
e-ISSN
1532-1827
Zeitschrift
British Journal of Cancer BJC
Quellenangaben
Band: 94,
Heft: 10,
Seiten: 1472-1477
Verlag
Nature Publishing Group
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Molecular Radiation Biology (IMS)
Institute of Pathology (PATH)
Institute of Pathology (PATH)
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Enabling and Novel Technologies
Enabling and Novel Technologies
PSP-Element(e)
G-500400-002
G-500300-001
G-500300-001
PubMed ID
16641909
Erfassungsdatum
2006-10-30