PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Dimou, L. ; Gallo, V.*

NG2-glia and their functions in the central nervous system.

Glia 63, 1429-1451 (2015)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
In the central nervous system, NG2-glia represent a neural cell population that is distinct from neurons, astrocytes, and oligodendrocytes. While in the past the main role ascribed to these cells was that of progenitors for oligodendrocytes, in the last years it has become more obvious that they have further functions in the brain. Here, we will discuss some of the most current and highly debated issues regarding NG2-glia: Do these cells represent a heterogeneous population? Can they give rise to different progenies, and does this change under pathological conditions? How do they respond to injury or pathology? What is the role of neurotransmitter signaling between neurons and NG2-glia? We will first give an overview on the developmental origin of NG2-glia, and then discuss whether their distinct properties in different brain regions are the result of environmental influences, or due to intrinsic differences. We will then review and discuss their in vitro differentiation potential and in vivo lineage under physiological and pathological conditions, together with their electrophysiological properties in distinct brain regions and at different developmental stages. Finally, we will focus on their potential to be used as therapeutic targets in demyelinating and neurodegenerative diseases. Therefore, this review article will highlight the importance of NG2-glia not only in the healthy, but also in the diseased brain.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
6.031
1.293
132
140
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Disease ; Heterogeneity ; Lineage Potential ; Oligodendrocyte Progenitors ; Physiology; Oligodendrocyte Precursor Cells; Glial Progenitor Cells; Spinal-cord-injury; Subcortical White-matter; Neural Stem-cells; Amyotrophic-lateral-sclerosis; Adult Cerebral-cortex; Experimental Autoimmune Encephalomyelitis; Olig Gene-function; Rat Barrel Cortex
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 0894-1491
e-ISSN 1098-1136
Zeitschrift Glia
Quellenangaben Band: 63, Heft: 8, Seiten: 1429-1451 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-500800-001
DOI 10.1002/glia.22859
WOS ID WOS:000356385000012
Scopus ID 84930872206
Scopus ID 84930030208
Erfassungsdatum 2015-06-06
[➜Korrektur melden]