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Knauer-Arloth, J.* ; Bogdan, R.* ; Weber, P.* ; Frishman, G. ; Menke, A.* ; Wagner, K.V.* ; Balsevich, G.* ; Schmidt, M.V.* ; Karbalai, N.* ; Czamara, D.* ; Altmann, A.* ; Trümbach, D. ; Wurst, W. ; Mehta, D.* ; Uhr, M.* ; Klengel, T.* ; Erhardt, A.* ; Carey, C.E.* ; Conley, E.D.* ; Ruepp, A. ; Müller-Myhsok, B.* ; Hariri, A.R.* ; Binder, E.B.*

Genetic differences in the immediate transcriptome response to stress predict risk-related brain function and psychiatric disorders.

Neuron 86, 1189-1202 (2015)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Depression risk is exacerbated by genetic factors and stress exposure; however, the biological mechanisms through which these factors interact to confer depression risk are poorly understood. One putative biological mechanism implicates variability in the ability of cortisol, released in response to stress, to trigger a cascade of adaptive genomic and non-genomic processes through glucocorticoid receptor (GR) activation. Here, we demonstrate that common genetic variants in long-range enhancer elements modulate the immediate transcriptional response to GR activation in human blood cells. These functional genetic variants increase risk for depression and co-heritable psychiatric disorders. Moreover, these risk variants are associated with inappropriate amygdala reactivity, a transdiagnostic psychiatric endophenotype and an important stress hormone response trigger. Network modeling and animal experiments suggest that these genetic differences in GR-induced transcriptional activation may mediate the risk for depression and other psychiatric disorders by altering a network of functionally related stress-sensitive genes in blood and brain.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Genome-wide Association; Glucocorticoid-receptor; Major Depression; Life Events; Schizophrenia; Environment; Expression; Disease
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 0896-6273
e-ISSN 1097-4199
Zeitschrift Neuron
Quellenangaben Band: 86, Heft: 5, Seiten: 1189-1202 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
Institute of Bioinformatics and Systems Biology (IBIS)
POF Topic(s) 30204 - Cell Programming and Repair
30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er) Genetics and Epidemiology
Enabling and Novel Technologies
PSP-Element(e) G-500500-001
G-503700-001
PubMed ID 26050039
DOI 10.1016/j.neuron.2015.05.034
WOS ID WOS:000355666400011
Scopus ID 84930526889
Erfassungsdatum 2015-06-09
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