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Morath, C.* ; Schmied, B.* ; Mehrabi, A.* ; Weitz, J.* ; Schmidt, J.* ; Werner, J.* ; Büchler, M.W.* ; Morcos, M.* ; Nawroth, P.P.* ; Schwenger, V.* ; Doehler, B.* ; Opelz, G.* ; Zeier, M.*

Angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers after renal transplantation.

Clin. Transplant. 23, 33-36 (2009)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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Renin-angiotensin system blockade retards the progression of diabetic and non-diabetic chronic kidney disease of the native kidneys. Though most patients suffer from a significant renal insufficiency (chronic kidney disease stage III) and a concomitant heart disease after renal transplantation, there is up to now no evidence supporting the use of inhibitors of the renin-angiotensin system in these patients. We wish to summarize the available evidence on the use of inhibitors of the renin-angiotensin system after renal transplantation. We specifically discuss potential beneficial as well as adverse effects of a renin-angiotensin system blockade. In addition, we review their influence on morphologic and biochemical markers as well as on renal function, graft and patient survival after renal transplantation.

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