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Herder, C.* ; Bongaerts, B.W.* ; Ouwens, D.M.* ; Rathmann, W.* ; Heier, M. ; Carstensen-Kirberg, M.* ; Koenig, W.* ; Thorand, B. ; Roden, M.* ; Meisinger, C. ; Ziegler, D.* ; KORA Study Group (Gieger, C. ; Grallert, H. ; Heinrich, J. ; Holle, R. ; Leidl, R. ; Peters, A. ; Strauch, K.)

Low serum omentin levels in the elderly population with type 2 diabetes and polyneuropathy.

Diabetic Med. 32, 1479-1483 (2015)

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AIMS: To investigate the hypothesis that high serum levels of omentin, an adipokine with anti-inflammatory, insulin-sensitizing and cardioprotective properties, may be related to a lower risk of diabetic sensorimotor polyneuropathy. METHODS: The association between serum omentin level and polyneuropathy was estimated in people aged 61-82 years with Type 2 diabetes (47 with and 168 without polyneuropathy) from the population-based KORA F4 study. The presence of clinical diabetic sensorimotor polyneuropathy was defined as bilateral impairment of foot vibration perception and/or foot pressure sensation. Omentin levels were determined by enzyme-linked immunosorbent assay. RESULTS: Serum omentin level was inversely associated with polyneuropathy after adjustment for age, sex, height, waist circumference, hypertension, total cholesterol, smoking, alcohol intake and physical activity [odds ratio 0.45 (95% CI 0.21-0.98); P = 0.043]. Although omentin was positively correlated with adiponectin (r = 0.55, P < 0.0001) and inversely with tumour necrosis factor-α (r = -0.30, P = 0.019), additional adjustment for adiponectin and tumour necrosis factor-α had little impact on the association. CONCLUSIONS: Serum levels of omentin are reduced in people with Type 2 diabetes and diabetic sensorimotor polyneuropathy, independently of established risk factors of polyneuropathy. This association is only partially explained by biomarkers of subclinical inflammation.

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