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Friedrich, N.* ; Budde, K.* ; Suhre, K. ; Völker, U.* ; John, U.* ; Felix, S.B.* ; Kroemer, H.K.* ; Grabe, H.J.* ; Völzke, H.* ; Nauck, M.* ; Wallaschofski, H.*

Sex differences in urine metabolites related with risk of diabetes using NMR spectroscopy: Results of the study of health in pomerania.

Metabolomics 11, 1405-1415 (2015)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Recently research provides evidence that blood metabolite profiles predicted type 2 diabetes. We aimed to assess the relation of urine metabolites measured via nuclear magnetic resonance spectroscopy with incident type 2 diabetes in a sample of 1353 men and 1356 women. Within 5 years, 87 men and 50 women developed diabetes. Five and 16 urine metabolites were associated with incident diabetes in men and women, respectively. Only three of these metabolites (glucose, lactate and glycine) were found in both sexes. In women, e.g. acetate, carnitine, N,N-dimethylglycine, trigonelline, 3-hydroxyisovalerate, alanine, formate, glycolate, trimethylamine N-oxide and tau-methylhistidine were positively related with diabetes. Receiver operating characteristic (ROC) analysis revealed that compared with a standard model, a model additionally adjusted for urine glucose, trigonelline and trimethylamine N-oxide levels showed a better discrimination between incident diabetes cases and non-cases in women (AUC = 0.874 and 0.903, p = 0.019). In men, valine and 4-hydroxyphenylacetate were found as markers of diabetes. However, ROC analysis did not reveal any improvement in discrimination based on urine metabolites. In conclusion, we confirmed the potential of metabolomics to assess the risk of type 2 diabetes and detected pronounced sex differences. Moreover, we demonstrated the practicability of spot urine samples as potential non-invasive diabetes screening approach.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Diabetes ; Metabolomics ; Nmr ; Sex Differences ; Urine; C-reactive Protein; Glycine Betaine Excretion; Trimethylamine-n-oxide; Glucose-tolerance Test; Insulin Sensitivity; Cardiovascular Risk; Gender-differences; Inflammatory Markers; Plasma-glucose; Adipose-tissue
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 1573-3882
e-ISSN 1573-3890
Zeitschrift Metabolomics
Quellenangaben Band: 11, Heft: 5, Seiten: 1405-1415 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Bioinformatics and Systems Biology (IBIS)
POF Topic(s) 30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503700-001
DOI 10.1007/s11306-015-0795-6
WOS ID WOS:000360715300034
Scopus ID 84941025074
Scopus ID 84926145703
Erfassungsdatum 2015-07-01
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