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Deussing, J.M.* ; Breu, J.* ; Kühne, C.* ; Kallnik, M. ; Bunck, M.* ; Glasl, L. ; Yen, Y.C.* ; Schmidt, M.V.* ; Zurmühlen, R.* ; Vogl, A.M.* ; Gailus-Durner, V. ; Fuchs, H. ; Hölter, S.M. ; Wotjak, C.T.* ; Landgraf, R.* ; Hrabě de Angelis, M. ; Holsboer, F.* ; Wurst, W.

Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2.

J. Neurosci. 30, 9103-9116 (2010)
Verlagsversion DOI PMC
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Urocortin 3 (UCN3) is strongly expressed in specific nuclei of the rodent brain, at sites distinct from those expressing urocortin 1 and urocortin 2, the other endogenous ligands of corticotropin-releasing hormone receptor type 2 (CRH-R2). To determine the physiological role of UCN3, we generated UCN3-deficient mice, in which the UCN3 open reading frame was replaced by a tau-lacZ reporter gene. By means of this reporter gene, the nucleus parabrachialis and the premammillary nucleus were identified as previously unknown sites of UCN3 expression. Additionally, the introduced reporter gene enabled the visualization of axonal projections of UCN3-expressing neurons from the superior paraolivary nucleus to the inferior colliculus and from the posterodorsal part of the medial amygdala to the principal nucleus of the bed nucleus of the stria terminalis, respectively. The examination of tau-lacZ reporter gene activity throughout the brain underscored a predominant expression of UCN3 in nuclei functionally connected to the accessory olfactory system. Male and female mice were comprehensively phenotyped but none of the applied tests provided indications for a role of UCN3 in the context of hypothalamic-pituitary-adrenocortical axis regulation, anxiety- or depression-related behavior. However, inspired by the prevalent expression throughout the accessory olfactory system, we identified alterations in social discrimination abilities of male and female UCN3 knock-out mice that were also present in male CRH-R2 knock-out mice. In conclusion, our results suggest a novel role for UCN3 and CRH-R2 related to the processing of social cues and to the establishment of social memories.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Acoustic Stimulation/methods; Animals; Brain/cytology; Brain/metabolism; Circadian Rhythm/physiology; Corticosterone/blood; Discrimination (Psychology)/physiology*; Fear/physiology; Female; Gene Expression Regulation/genetics; Hypothalamo-Hypophyseal System/metabolism; Inhibition (Psychology); Interpersonal Relations*; Male; Maze Learning/physiology; Mice; Mice; Inbred C57BL; Mice; Knockout; Neurons/metabolism; Odors; Olfactory Pathways/physiology; Perception/physiology; Pituitary-Adrenal System/embryology;
Sprache englisch
Veröffentlichungsjahr 2010
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 0270-6474
e-ISSN 1529-2401
Zeitschrift Journal of Neuroscience
Quellenangaben Band: 30, Heft: 27, Seiten: 9103-9116 Artikelnummer: , Supplement: ,
Verlag Society for Neuroscience
Verlagsort Washington
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
Institute of Experimental Genetics (IEG)
POF Topic(s) 30204 - Cell Programming and Repair
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30201 - Metabolic Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500500-001
G-520600-001
G-500600-003
G-500600-001
DOI 10.1523/JNEUROSCI.1049-10.2010
Scopus ID 77954515779
PubMed ID 20610744
Erfassungsdatum 2010-07-13
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