PuSH - Publikationsserver des Helmholtz Zentrums München: Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Boulet, M.M.* ; Chevrier, G.* ; Grenier-Larouche, T.* ; Pelletier, M.P.* ; Nadeau, M.* ; Scarpa, J. ; Prehn, C. ; Marette, A.* ; Adamski, J. ; Tchernof, A.*

Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk.

Am. J. Physiol. Endocrinol. Metab. 309, E736-E746 (2015)

Postprint

DOI

PMC

Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.

Abstract
Metriken
Zusatzinfos

CONTEXT: Metabolomic profiling of obese individuals revealed altered concentrations of many metabolites, especially branched-chain amino acids (BCAA), possibly linked to altered adipose tissue BCAA catabolism. OBJECTIVE: We tested the hypothesis that some features of this metabolite signature relate closely to visceral obesity and concomitant alterations in cardiometabolic risk factors. We also postulated that alterations in BCAA-catabolizing enzymes are predominant in visceral adipose tissue. METHODS: Fifty-nine women (BMI 20-41 kg/m(2)) undergoing gynecologic surgery were recruited and characterized for overall and regional adiposity, blood metabolite levels using targeted metabolomics and cardiometabolic risk factors. Adipose samples (visceral and subcutaneous) were obtained and used for gene expression and western blot analyses. RESULTS: Obese women had significantly higher circulating BCAA and Kynurenine/Tryptophan (KYN/Trp) ratio than lean or overweight women (p<0.01). Principal component analysis confirmed that factors related to AA and the KYN/Trp ratio were positively associated with BMI, fat mass, visceral or subcutaneous adipose tissue area and subcutaneous adipocyte size (p≤0.05). AA-related factor was positively associated with HOMA-IR (p≤0.01). Factors reflecting glycerophospholipids and sphingolipids levels were mostly associated with altered blood lipid concentrations (p≤0.05). Glutamate level was the strongest independent predictor of visceral adipose tissue area (r=0.46, p<0.001). Obese women had lower expression and protein levels of BCAA-catabolizing enzymes in visceral adipose tissue compared to overweight or lean women (p≤0.05). CONCLUSIONS: Among metabolites altered in obesity, plasma concentrations of BCAA and the KYN/Trp ratio are closely related to increased adiposity. Alterations in expression and protein levels of BCAA-catabolizing enzymes are predominant in visceral adipose tissue.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

3.785

1.164