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    Analysis of EPR and FISH studies of radiation doses in persons who lived in the upper reaches of the Techa River.
        
        Radiat. Environ. Biophys. 54, 433-444 (2015)
    
    
    
				Waterborne radioactive releases into the Techa River from the Mayak Production Association in Russia during 1949–1956 resulted in significant doses to about 30,000 persons who lived in downstream settlements. The residents were exposed to internal and external radiation. Two methods for reconstruction of the external dose are considered in this paper, electron paramagnetic resonance (EPR) measurements of teeth, and fluorescence in situ hybridization (FISH) measurements of chromosome translocations in circulating lymphocytes. The main issue in the application of the EPR and FISH methods for reconstruction of the external dose for the Techa Riverside residents was strontium radioisotopes incorporated in teeth and bones that act as a source of confounding local exposures. In order to estimate and subtract doses from incorporated 89,90Sr, the EPR and FISH assays were supported by measurements of 90Sr-body burdens and estimates of 90Sr concentrations in dental tissues by the luminescence method. The resulting dose estimates derived from EPR to FISH measurements for residents of the upper Techa River were found to be consistent: The mean values vary from 510 to 550 mGy for the villages located close to the site of radioactive release to 130–160 mGy for the more distant villages. The upper bound of individual estimates for both methods is equal to 2.2–2.3 Gy. The EPR- and FISH-based dose estimates were compared with the doses calculated for the donors using the most recent Techa River Dosimetry System (TRDS). The TRDS external dose assessments are based on the data on contamination of the Techa River floodplain, simulation of air kerma above the contaminated soil, age-dependent lifestyles and individual residence histories. For correct comparison, TRDS-based doses were calculated from two sources: external exposure from the contaminated environment and internal exposure from 137Cs incorporated in donors’ soft tissues. It is shown here that the TRDS-based absorbed doses in tooth enamel and muscle are in agreement with EPR- and FISH-based estimates within uncertainty bounds. Basically, this agreement between the estimates has confirmed the validity of external doses calculated with the TRDS.
			
			
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        Publikationstyp
        Artikel: Journalartikel
    
 
    
        Dokumenttyp
        Wissenschaftlicher Artikel
    
 
     
    
    
        Schlagwörter
        Dose Reconstruction ; Electron Paramagnetic Resonance ; Environmental Contamination ; Fluorescence In Situ Hybridization ; Techa River
    
 
     
    
    
        Sprache
        englisch
    
 
    
        Veröffentlichungsjahr
        2015
    
 
     
    
        HGF-Berichtsjahr
        2015
    
 
    
    
        ISSN (print) / ISBN
        0301-634X
    
 
    
        e-ISSN
        1432-2099
    
 
     
     
     
	     
	 
	 
    
        Zeitschrift
        Radiation and Environmental Biophysics
    
 
		
    
        Quellenangaben
        
	    Band: 54,  
	    Heft: 4,  
	    Seiten: 433-444 
	    
	    
	
    
 
  
         
        
            Verlag
            Springer
        
 
         
	
         
         
         
         
         
	
         
         
         
    
         
         
         
         
         
         
         
    
        Begutachtungsstatus
        Peer reviewed
    
 
    
        Institut(e)
        Institute of Radiation Protection (ISS)
    
 
    
        POF Topic(s)
        30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
    
 
    
        Forschungsfeld(er)
        Radiation Sciences
    
 
    
        PSP-Element(e)
        G-501100-005
    
 
     
     	
    
    
        WOS ID
        WOS:000364028400005
    
    
        Scopus ID
        84937950552
    
    
        Erfassungsdatum
        2015-09-21