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Hector, A.* ; Kormann, M.S.* ; Mack, I.* ; Latzin, P.* ; Casaulta, C.* ; Kieninger, E.* ; Zhou, Z.* ; Yildirim, A.Ö. ; Bohla, A. ; Rieber, N.* ; Kappler, M.* ; Koller, B.* ; Eber, E.* ; Eickmeier, O.* ; Zielen, S.* ; Eickelberg, O. ; Griese, M.* ; Mall, M.A.* ; Hartl, D.*

The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease.

PLoS ONE 6:e24399 (2011)
Verlagsversion Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The chitinase-like protein YKL-40 was found to be increased in patients with severe asthma and chronic obstructive pulmonary disease (COPD), two disease conditions featuring neutrophilic infiltrates. Based on these studies and a previous report indicating that neutrophils secrete YKL-40, we hypothesized that YKL-40 plays a key role in cystic fibrosis (CF) lung disease, a prototypic neutrophilic disease. The aim of this study was (i) to analyze YKL-40 levels in human and murine CF lung disease and (ii) to investigate whether YKL-40 single-nucleotide polymorphisms (SNPs) modulate CF lung disease severity. YKL-40 protein levels were quantified in serum and sputum supernatants from CF patients and control individuals. Levels of the murine homologue BRP-39 were analyzed in airway fluids from CF-like βENaC-Tg mice. YKL-40SNPs were analyzed in CF patients. YKL-40 levels were increased in sputum supernatants and in serum from CF patients compared to healthy control individuals. Within CF patients, YKL-40 levels were higher in sputum than in serum. BRP-39 levels were increased in airways fluids from βENaC-Tg mice compared to wild-type littermates. In both CF patients and βENaC-Tg mice, YKL-40/BRP-39 airway levels correlated with the severity of pulmonary obstruction. Two YKL-40 SNPs (rs871799 and rs880633) were found to modulate age-adjusted lung function in CF patients. YKL-40/BRP-39 levelsare increased in human and murine CF airway fluids, correlate with pulmonary function and modulate CF lung disease severity genetically. These findings suggest YKL-40 as a potential biomarker in CF lung disease.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter MAMMALIAN MEMBER; SEVERE ASTHMA; SERUM-LEVELS; NEUTROPHILS; INFLAMMATION; CELLS; IDENTIFICATION; MACROPHAGES; INVOLVEMENT; EXPRESSION
Sprache englisch
Veröffentlichungsjahr 2011
HGF-Berichtsjahr 2011
ISSN (print) / ISBN 1932-6203
Zeitschrift PLoS ONE
Quellenangaben Band: 6, Heft: 9, Seiten: , Artikelnummer: e24399 Supplement: ,
Verlag Public Library of Science (PLoS)
Verlagsort Lawrence, Kan.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-501600-001
G-505000-007
PubMed ID 21949714
DOI 10.1371/journal.pone.0024399
WOS ID WOS:000295260400005
WOS ID 000295260400005
Erfassungsdatum 2011-11-07
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