PuSH - Publikationsserver des Helmholtz Zentrums München: The transcriptional landscape of age in human peripheral blood.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Peters, M.J.* ; Joehanes, R.* ; Pilling, L.C.* ; Schurmann, C.* ; Conneely, K.N.* ; Powell, J.* ; Reinmaa, E.* ; Sutphin, G.L.* ; Zhernakova, A.* ; Schramm, K. ; Wilson, Y.A.* ; Kobes, S.* ; Tukiainen, T.* ; Ramos, Y.F.* ; Göring, H.H.H.* ; Fornage, M.* ; Liu, Y.* ; Gharib, S.A.* ; Stranger, B.E.* ; de Jager, P.L.* ; Aviv, A.* ; Levy, D.* ; Murabito, J.M.* ; Munson, P.J.* ; Huan, T.* ; Hofman, A.* ; Uitterlinden, A.G.* ; Rivadeneira, F.* ; van Rooij, J.* ; Stolk, L.* ; Broer, L.* ; Verbiest, M.M.P.J.* ; Jhamai, M.* ; Arp, P.* ; Metspalu, A.* ; Tserel, L.* ; Milani, L.* ; Samani, N.J.* ; Peterson, P.* ; Kasela, S.* ; Codd, V.* ; Peters, A. ; Ward-Caviness, C.K. ; Herder, C.* ; Waldenberger, M. ; Roden, M.* ; Singmann, P. ; Zeilinger, S. ; Illig, T.* ; Homuth, G.* ; Grabe, H.J.* ; Völzke, H.* ; Steil, L.* ; Kocher, T.* ; Martin, N.G.* ; Smith, A.K.* ; Mehta, D.* ; Binder, E.B.* ; Nylocks, K.M.* ; Kennedy, E.M.* ; Klengel, T.* ; Ding, J.* ; Suchy-Dicey, A.* ; Enquobahrie, D.A.* ; Houwing-Duistermaat, J.J.* ; Slagboom, P.E.* ; Helmer, Q.* ; den Hollander, W.* ; Raj, T.* ; Oyston, L.J.* ; Turner, S.T.* ; Blangero, J.* ; Brody, J.* ; Rotter, J.I.* ; Chen, Y.D.* ; Kloppenburg, M.* ; Bean, S.* ; Bakhshi, N.* ; Wang, Q.P.* ; Psaty, B.M.* ; Tracy, R.P.* ; Montgomery, G.W.* ; Meulenbelt, I.* ; Ressler, K.J.* ; Yang, J.* ; Franke, L.* ; Kettunen, J.* ; Visscher, P.M.* ; Neely, G.G.* ; Korstanje, R.* ; Hanson, R.L.* ; Prokisch, H. ; Ferrucci, L.* ; Esko, T.* ; Teumer, A.* ; van Meurs, J.B.* ; Johnson, A.D.*

The transcriptional landscape of age in human peripheral blood.

Nat. Commun. 6:8570 (2015)

Verlagsversion

Forschungsdaten

DOI

PMC

	Open Access Gold

Abstract
Metriken
Zusatzinfos

Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the 'transcriptomic age' of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

11.470

3.052

262

339