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möglich sobald bei der ZB eingereicht worden ist.
Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors.
Blood 127, 139-148 (2016)
Verlagsversion
Postprint
DOI
PMC
Maintaining cellular redox balance is vital for cell survival and tissue homoeostasis since imbalanced production of ROS may lead to oxidative stress and cell death. The anti-oxidant enzyme glutathione peroxidase 4 (Gpx4) is a key regulator of oxidative stress-induced cell death. We show that mice with deletion of Gpx4 in hematopoietic cells develop anemia and that it is essential for preventing RIP3 dependent necroptosis in erythroid precursor cells. Absence of Gpx4 leads to functional inactivation of caspase 8 by glutathionylation. This results in necroptosis, which occurs independently of TNFα activation. While genetic ablation of Rip3 normalizes reticulocyte maturation and prevents anemia, ROS accumulation and lipid peroxidation in Gpx4 deficient cells remain high. Our results demonstrate that ROS and lipid hydroperoxides function as so far unrecognized unconventional upstream signaling activators of RIP3-dependent necroptosis.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
11.841
2.502
94
102
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Gpx4 Is Essential For Preventing Anemia In Mice Via Inhibiting Rip3-dependent Necroptosis In Erythroid Precursor Cells ; Ros Accumulation And Lipid Peroxidation In Erythroid Precursor Cells Trigger Receptor-independent Activation Of Necroptosis; Tumor-necrosis-factor; Cell-death; Programmed Necrosis; Hydrogen-peroxide; Inflammation; Apoptosis; Mice; Homeostasis; Ferroptosis; Protects
Sprache
englisch
Veröffentlichungsjahr
2016
Prepublished im Jahr
2015
HGF-Berichtsjahr
2015
ISSN (print) / ISBN
0006-4971
e-ISSN
1528-0020
Zeitschrift
Blood
Quellenangaben
Band: 127,
Heft: 1,
Seiten: 139-148
Verlag
American Society of Hematology
Verlagsort
Washington
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Stem Cell Research (ISF)
Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
POF Topic(s)
30204 - Cell Programming and Repair
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Stem Cell and Neuroscience
Immune Response and Infection
Immune Response and Infection
PSP-Element(e)
G-500800-001
G-501400-006
G-501490-001
G-501400-005
G-501400-006
G-501490-001
G-501400-005
WOS ID
WOS:000369281300023
Scopus ID
84955476379
PubMed ID
26463424
Erfassungsdatum
2015-11-04