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Assessing cognition in mice.
Curr. Protoc. Mouse Biol. 5, 331-358:doi: 10.1002/9780470942390.mo160 (2015)
Genetically modified mouse models have proven useful to study learning and memory processes and the neurocircuitry and molecular mechanisms involved, as well as to develop therapies for diseases involving cognitive impairment. A variety of tests have been developed to measure cognition in mice, and here we present those established and regularly used in the German Mouse Clinic. The test paradigms have been carefully chosen according to reliability of results and disease relevance of the cognitive functions assessed. Further criteria were time efficiency and ease of application. All tests assess slightly different but also overlapping or interacting aspects of learning and memory so that they can be used to complement each other in a comprehensive assessment of cognitive function. The five protocols described are for spontaneous alternation in the Y-maze, social discrimination, object recognition, automated assessment of learning and memory using the IntelliCage, and olfactory discrimination learning.
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39
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Intellicage ; Y-maze ; Object Recognition ; Olfactory Discrimination Learning ; Social Discrimination
Sprache
Veröffentlichungsjahr
2015
HGF-Berichtsjahr
0
ISSN (print) / ISBN
2161-2617
Zeitschrift
Current Protocols of Mouse Biology
Quellenangaben
Band: 5,
Heft: 5,
Seiten: 331-358,
Artikelnummer: doi: 10.1002/9780470942390.mo160
Verlag
Wiley
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30204 - Cell Programming and Repair
30201 - Metabolic Health
30201 - Metabolic Health
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-500500-001
G-500600-001
G-500692-001
G-500500-005
G-500600-001
G-500692-001
G-500500-005
PubMed ID
26629775
Erfassungsdatum
2015-12-07