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Viganò, F. ; Schneider, S.* ; Cimino, M.* ; Bonfanti, E.* ; Gelosa, P.* ; Sironi, L.* ; Abbracchio, M.P.* ; Dimou, L.

GPR17 expressing NG2-Glia: Oligodendrocyte progenitors serving as a reserve pool after injury.

Glia 64, 287-299 (2015)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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In the adult brain NG2-glia continuously generate mature, myelinating oligodendrocytes. To which extent the differentiation process is common to all NG2-glia and whether distinct pools are recruited for repair under physiological and pathological conditions still needs clarification. Here, we aimed at investigating the differentiation potential of adult NG2-glia that specifically express the G-protein coupled receptor 17 (GPR17), a membrane receptor that regulates the differentiation of these cells at postnatal stages. To this aim, we generated the first BAC transgenic GPR17-iCreERT2 mouse line for fate mapping studies. In these mice, under physiological conditions, GPR17+ cells -in contrast to GPR17- NG2-glia- did not differentiate within 3 months, a peculiarity that was overcome after cerebral damage induced by acute injury or ischemia. After these insults, GPR17+ NG2-glia rapidly reacted to the damage and underwent maturation, suggesting that they represent a 'reserve pool' of adult progenitors maintained for repair purposes.

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