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möglich sobald bei der ZB eingereicht worden ist.
Pitchfork and Gprasp2 target smoothened to the primary cilium for Hedgehog pathway activation.
PLoS ONE 11:e0149477 (2016)
The seven-transmembrane receptor Smoothened (Smo) activates all Hedgehog (Hh) signaling by translocation into the primary cilia (PC), but how this is regulated is not well understood. Here we show that Pitchfork (Pifo) and the G protein-coupled receptor associated sorting protein 2 (Gprasp2) are essential components of an Hh induced ciliary targeting complex able to regulate Smo translocation to the PC. Depletion of Pifo or Gprasp2 leads to failure of Smo translocation to the PC and lack of Hh target gene activation. Together, our results identify a novel protein complex that is regulated by Hh signaling and required for Smo ciliary trafficking and Hh pathway activation.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
3.057
1.034
20
21
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Protein-coupled Receptors; Intraflagellar Transport Proteins; Embryonic Stem-cells; Neuronal Cilia; Localization; Mice; Identification; Ciliopathies; Ciliogenesis; Trafficking
Sprache
englisch
Veröffentlichungsjahr
2016
HGF-Berichtsjahr
2016
ISSN (print) / ISBN
1932-6203
Zeitschrift
PLoS ONE
Quellenangaben
Band: 11,
Heft: 2,
Artikelnummer: e0149477
Verlag
Public Library of Science (PLoS)
Verlagsort
Lawrence, Kan.
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes and Regeneration Research (IDR)
Institute of Diabetes and Obesity (IDO)
Institute of Computational Biology (ICB)
Institute of Structural Biology (STB)
Institute of Molecular Immunology (IMI)
CF Metabolomics & Proteomics (CF-MPC)
Institute of Diabetes and Obesity (IDO)
Institute of Computational Biology (ICB)
Institute of Structural Biology (STB)
Institute of Molecular Immunology (IMI)
CF Metabolomics & Proteomics (CF-MPC)
POF Topic(s)
30201 - Metabolic Health
30205 - Bioengineering and Digital Health
30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30205 - Bioengineering and Digital Health
30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Helmholtz Diabetes Center
Enabling and Novel Technologies
Immune Response and Infection
Enabling and Novel Technologies
Immune Response and Infection
PSP-Element(e)
G-502300-001
G-502200-001
G-503800-001
G-503000-001
G-503000-003
G-501793-001
G-505700-001
G-502200-001
G-503800-001
G-503000-001
G-503000-003
G-501793-001
G-505700-001
PubMed ID
26901434
WOS ID
WOS:000371276100080
Scopus ID
84960538904
Erfassungsdatum
2016-02-25