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Tepper, S.* ; Jeschke, J. ; Böttcher, K.* ; Schmidt, A.* ; Davari, K.* ; Müller, P.* ; Kremmer, E. ; Hemmerich, P.* ; Pfeil, I. ; Jungnickel, B.

PARP activation promotes nuclear AID accumulation in lymphoma cells.

Oncotarget 7, 13197-13208 (2016)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Activation-induced cytidine deaminase (AID) initiates immunoglobulin diversification in germinal center B cells by targeted introduction of DNA damage. As aberrant nuclear AID action contributes to the generation of B cell lymphoma, the protein's activity is tightly regulated, e.g. by nuclear/cytoplasmic shuttling and nuclear degradation. In the present study, we asked whether DNA damage may affect regulation of the AID protein. We show that exogenous DNA damage that mainly activates base excision repair leads to prevention of proteasomal degradation of AID and hence its nuclear accumulation. Inhibitor as well as knockout studies indicate that activation of poly (ADP-ribose) polymerase (PARP) by DNA damaging agents promotes both phenomena. These findings suggest that PARP inhibitors influence DNA damage dependent AID regulation, with interesting implications for the regulation of AID function and chemotherapy of lymphoma.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dna Damage ; Activation-induced Cytidine Deaminase ; Lymphoma ; Poly (adp-ribose) Polymerase ; Protein Stability; Induced Cytidine Deaminase; Class-switch Recombination; Dna-damage Response; Protein-kinase-a; Somatic Hypermutation; Homologous Recombination; Genomic Uracil; B-cells; Phosphorylation; Mechanisms
Sprache englisch
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 1949-2553
e-ISSN 1949-2553
Zeitschrift OncoTarget
Quellenangaben Band: 7, Heft: 11, Seiten: 13197-13208 Artikelnummer: , Supplement: ,
Verlag Impact Journals LLC
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
Institute of Molecular Immunology (IMI)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501490-001
G-501793-001
DOI 10.18632/oncotarget.7603
WOS ID WOS:000375679600108
Scopus ID 84962868923
PubMed ID 26921193
Erfassungsdatum 2016-02-29
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