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Serr, I. ; Fürst, R. ; Achenbach, P. ; Scherm, M.G. ; Gökmen, F. ; Haupt, F. ; Sedlmeier, E.-M. ; Knopff, A. ; Shultz, L.* ; Willis, R.A.* ; Ziegler, A.-G. ; Daniel, C.

Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice.

Nat. Commun. 7:10991 (2016)
Verlagsversion Anhang DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Immune tolerance is executed partly by Foxp3(+)regulatory T (Treg) cells, which suppress autoreactive T cells. In autoimmune type 1 diabetes (T1D) impaired tolerance promotes destruction of insulin-producing β-cells. The development of autoantigen-specific vaccination strategies for Foxp3(+)Treg-induction and prevention of islet autoimmunity in patients is still in its infancy. Here, using human haematopoietic stem cell-engrafted NSG-HLA-DQ8 transgenic mice, we provide direct evidence for human autoantigen-specific Foxp3(+)Treg-induction in vivo. We identify HLA-DQ8-restricted insulin-specific CD4(+)T cells and demonstrate efficient human insulin-specific Foxp3(+)Treg-induction upon subimmunogenic vaccination with strong agonistic insulin mimetopes in vivo. Induced human Tregs are stable, show increased expression of Treg signature genes such as Foxp3, CTLA4, IL-2Rα and TIGIT and can efficiently suppress effector T cells. Such Foxp3(+)Treg-induction does not trigger any effector T cells. These T1D vaccine candidates could therefore represent an expedient improvement in the challenge to induce human Foxp3(+)Tregs and to develop novel precision medicines for prevention of islet autoimmunity in children at risk of T1D.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Regulatory T-cells; Class-ii Mhc; In-vivo; Nod Mice; Microneedle Patches; Immune-responses; High-risk; Insulin; Antigen; Tolerance
Sprache englisch
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Zeitschrift Nature Communications
Quellenangaben Band: 7, Heft: , Seiten: , Artikelnummer: 10991 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
POF Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502100-001
G-501900-212
PubMed ID 26975663
DOI 10.1038/ncomms10991
WOS ID WOS:000372189000001
Scopus ID 84962488594
Erfassungsdatum 2016-03-17
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