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Multiple lytic origins of replication are required for optimal gammaherpesvirus fitness in vitro and in vivo.
PLoS Pathog. 12:e1005510 (2016)
An unresolved question in herpesvirus biology is why some herpesviruses contain more than one lytic origin of replication (oriLyt). Using murine gammaherpesvirus 68 (MHV-68) as model virus containing two oriLyts, we demonstrate that loss of either of the two oriLyts was well tolerated in some situations but not in others both in vitro and in vivo. This was related to the cell type, the organ or the route of inoculation. Depending on the cell type, different cellular proteins, for example Hexim1 and Rbbp4, were found to be associated with oriLyt DNA. Overexpression or downregulation of these proteins differentially affected the growth of mutants lacking either the left or the right oriLyt. Thus, multiple oriLyts are required to ensure optimal fitness in different cell types and tissues.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
7.003
1.704
8
9
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Sarcoma-associated Herpesvirus; Dependent Dna-replication; Epstein-barr-virus; Bacterial Artificial Chromosome; Kaposis-sarcoma; Murine Gammaherpesvirus-68; Functional-characterization; Identification; Establishment; Transcription
Sprache
englisch
Veröffentlichungsjahr
2016
HGF-Berichtsjahr
2016
ISSN (print) / ISBN
1553-7366
e-ISSN
1553-7374
Zeitschrift
PLoS Pathogens
Quellenangaben
Band: 12,
Heft: 3,
Artikelnummer: e1005510
Verlag
Public Library of Science (PLoS)
Verlagsort
San Francisco
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Gene Vector (AGV)
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Immune Response and Infection
PSP-Element(e)
G-501500-006
PubMed ID
27007137
WOS ID
WOS:000378154800032
WOS ID
WOS:000372701200123
Scopus ID
84962339013
Erfassungsdatum
2016-04-04