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Talbert, P.B.* ; Ahmad, K.* ; Almouzni, G.* ; Ausió, J.* ; Berger, F.* ; Bhalla, P.L.* ; Bonner, W.M.* ; Cande, W.Z.* ; Chadwick, B.P.* ; Chan, S.W.* ; Cross, G.A.* ; Cui, L.* ; Dimitrov, S.I.* ; Doenecke, D.* ; Eirin-López, J.M.* ; Gorovsky, M.A.* ; Hake, S.B.* ; Hamkalo, B.A.* ; Holec, S.* ; Jacobsen, S.E.* ; Kamieniarz, K.* ; Khochbin, S.* ; Ladurner, A.G.* ; Landsman, D.* ; Latham, J.A.* ; Loppin, B.* ; Malik, H.S.* ; Marzluff, W.F.* ; Pehrson, J.R.* ; Postberg, J.* ; Schneider, R.* ; Singh, M.B.* ; Smith, M.M.* ; Thompson, E.E.* ; Torres-Padilla, M.E.* ; Tremethick, D.J.* ; Turner, B.M.* ; Waterborg, J.H.* ; Wollmann, H.* ; Yelagandula, R.* ; Zhu, B.M.* ; Henikoff, S.*

A unified phylogeny-based nomenclature for histone variants.

Epigenetics Chromatin 5:7 (2012)
DOI PMC
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Histone variants are non-allelic protein isoforms that play key roles in diversifying chromatin structure. The known number of such variants has greatly increased in recent years, but the lack of naming conventions for them has led to a variety of naming styles, multiple synonyms and misleading homographs that obscure variant relationships and complicate database searches. We propose here a unified nomenclature for variants of all five classes of histones that uses consistent but flexible naming conventions to produce names that are informative and readily searchable. The nomenclature builds on historical usage and incorporates phylogenetic relationships, which are strong predictors of structure and function. A key feature is the consistent use of punctuation to represent phylogenetic divergence, making explicit the relationships among variant subtypes that have previously been implicit or unclear. We recommend that by default new histone variants be named with organism-specific paralog-number suffixes that lack phylogenetic implication, while letter suffixes be reserved for structurally distinct clades of variants. For clarity and searchability, we encourage the use of descriptors that are separate from the phylogeny-based variant name to indicate developmental and other properties of variants that may be independent of structure.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 0
e-ISSN 1756-8935
Zeitschrift Epigenetics & Chromatin
Quellenangaben Band: 5, Heft: , Seiten: , Artikelnummer: 7 Supplement: ,
Verlag BioMed Central
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Functional Epigenetics (IFE)
Institute of Epigenetics and Stem Cells (IES)
POF Topic(s) 30203 - Molecular Targets and Therapies
30204 - Cell Programming and Repair
Forschungsfeld(er) Helmholtz Diabetes Center
Stem Cell and Neuroscience
PSP-Element(e) G-502800-001
G-506200-001
PubMed ID 22650316
DOI 10.1186/1756-8935-5-7
Erfassungsdatum 2012-12-31
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