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Scherm, M.G. ; Ott, V. ; Daniel, C.

Follicular helper T cells in autoimmunity.

Curr. Diab. Rep. 16:75 (2016)
Postprint DOI PMC
Open Access Green
The development of multiple disease-relevant autoantibodies is a hallmark of autoimmune diseases. In autoimmune type 1 diabetes (T1D), a variable time frame of autoimmunity precedes the clinically overt disease. The relevance of T follicular helper (TFH) cells for the immune system is increasingly recognized. Their pivotal contribution to antibody production by providing help to germinal center (GC) B cells facilitates the development of a long-lived humoral immunity. Their complex differentiation process, involving various stages and factors like B cell lymphoma 6 (Bcl6), is strictly controlled, as anomalous regulation of TFH cells is connected with immunopathologies. While the adverse effects of a TFH cell-related insufficient humoral immunity are obvious, the role of increased TFH frequencies in autoimmune diseases like T1D is currently highlighted. High levels of autoantigen trigger an excessive induction of TFH cells, consequently resulting in the production of autoantibodies. Therefore, TFH cells might provide promising approaches for novel therapeutic strategies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Autoantibodies ; Autoimmunity ; Biomarker ; Tfh Cells ; Type 1 Diabetes; Systemic-lupus-erythematosus; Cxc Chemokine Receptor-5; B-cells; In-vivo; Negative Regulator; Germinal-centers; Virus-infection; Mouse Model; Differentiation; Icos
Sprache englisch
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 1534-4827
e-ISSN 1539-0829
Zeitschrift Current Diabetes Reports
Quellenangaben Band: 16, Heft: 8, Seiten: , Artikelnummer: 75 Supplement: ,
Verlag Springer
Verlagsort Heidelberg [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
Institute of Diabetes and Obesity (IDO)
POF Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-501900-213
G-501900-212
G-502200-001
DOI 10.1007/s11892-016-0770-2
WOS ID WOS:000381995900009
Scopus ID 84976311618
PubMed ID 27324759
Erfassungsdatum 2016-07-04
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