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Masserdotti, G. ; Gascón, S. ; Götz, M.

Direct neuronal reprogramming: Learning from and for development.

Development 143, 2494-2510 (2016)
Verlagsversion DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The key signalling pathways and transcriptional programmes that instruct neuronal diversity during development have largely been identified. In this Review, we discuss how this knowledge has been used to successfully reprogramme various cell types into an amazing array of distinct types of functional neurons. We further discuss the extent to which direct neuronal reprogramming recapitulates embryonic development, and examine the particular barriers to reprogramming that may exist given a cell's unique developmental history. We conclude with a recently proposed model for cell specification called the 'Cook Islands' model, and consider whether it is a fitting model for cell specification based on recent results from the direct reprogramming field.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Conversion ; Direct Reprogramming ; Neurogenesis ; Neuron ; Neuronal Subtype ; Transcription Factor ; Transdifferentiation; Embryonic Stem-cells; Pioneer Transcription Factors; Mammalian Cerebral-cortex; Spinal Motor-neurons; Human Fibroblasts; Direct Conversion; Functional-neurons; Neural Stem; In-vivo; Dopaminergic-neurons
Sprache englisch
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 0950-1991
e-ISSN 1477-9129
Zeitschrift Development / Company of Biologists
Quellenangaben Band: 143, Heft: 14, Seiten: 2494-2510 Artikelnummer: , Supplement: ,
Verlag Company of Biologists
Verlagsort Cambridge
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-500800-001
DOI 10.1242/dev.092163
WOS ID WOS:000392715600003
Scopus ID 84978727354
PubMed ID 27436039
Erfassungsdatum 2016-07-25
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