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Klein, D. ; Kessler, W. ; Semder, B. ; Pütz, C. ; Lichtmannegger, J. ; Otter, R.* ; Filser, J.G.

Di-(2-propylheptyl) phthalate (DPHP) and its metabolites in blood of rats upon single oral administration of DPHP.

Toxicol. Lett. 259, 80-86 (2016)
Postprint DOI PMC
Open Access Green
Di-(2-propylheptyl) phthalate (DPHP) does not act as a reproductive toxicant or endocrine disruptor in contrast to other phthalates. Considering adverse effects of phthalates to be linked to their metabolism, it was the aim of the present study to investigate in the rat the blood burden of DPHP and its metabolites as a basis for understanding the toxicological behavior of DPHP. Rats were administered single oral doses of DPHP of 0.7 and 100mg/kg body weight. Concentration-time courses of DPHP and metabolites were monitored in blood. The areas under the concentration-time curves in blood (AUCs), normalized for the dose of DPHP, showed the following order: DPHP
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Di-(2-propylheptyl) Phthalate ; Blood ; Metabolites ; Oral Treatment ; Rat; Di(2-ethylhexyl) Phthalate; Di-(2-ethylhexyl) Phthalate; 2-ethylhexyl Phthalate; Male-volunteers; Disposition; Hydrolysis; Marmosets; Esters; Dehp; Excretion
Sprache
Veröffentlichungsjahr 2016
HGF-Berichtsjahr 2016
ISSN (print) / ISBN 0378-4274
e-ISSN 1879-3169
Zeitschrift Toxicology Letters
Quellenangaben Band: 259, Heft: , Seiten: 80-86 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Toxicology and Pharmacology (TOX)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-505200-002
G-505200-003
DOI 10.1016/j.toxlet.2016.07.025
WOS ID WOS:000385332000010
Scopus ID 84982850731
Scopus ID 84980729352
PubMed ID 27452279
Erfassungsdatum 2016-08-01
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