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Anal. Chem. 88, 10785-10789 (2016)
We introduce hyperpolarizable13C-labeled probes that identify multiple biologically important divalent metals via metal-specific chemical shifts. These features enable NMR measurements of calcium concentrations in human serum in the presence of magnesium. In addition, signal enhancement through dynamic nuclear polarization (DNP) increases the sensitivity of metal detection to afford measuring micromolar concentrations of calcium as well as simultaneous multi-metal detection by chemical shift imaging. The hyperpolarizable13C-MRI sensors presented here enable sensitive NMR measurements and MR imaging of multiple divalent metals in opaque biological samples.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
5.886
1.520
14
16
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Ligand-exchange Kinetics; Mri Contrast Agents; Calcium; C-13; Edta; Nmr; Probe; Ions; Sensitivity; Complexes
Sprache
Veröffentlichungsjahr
2016
HGF-Berichtsjahr
2016
ISSN (print) / ISBN
0003-2700
e-ISSN
1520-6882
Zeitschrift
Analytical Chemistry
Quellenangaben
Band: 88,
Heft: 22,
Seiten: 10785-10789
Verlag
American Chemical Society (ACS)
Verlagsort
Washington
Begutachtungsstatus
Peer reviewed
POF Topic(s)
30502 - Diabetes: Pathophysiology, Prevention and Therapy
30505 - New Technologies for Biomedical Discoveries
30505 - New Technologies for Biomedical Discoveries
Forschungsfeld(er)
Enabling and Novel Technologies
PSP-Element(e)
G-552000-002
G-552000-001
G-552000-001
WOS ID
WOS:000388154700003
Scopus ID
85045584016
PubMed ID
27766840
Erfassungsdatum
2016-11-02