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Burnett, C.J.* ; Li, C.* ; Webber, E.* ; Tsaousidou, E.* ; Xue, S.Y.* ; Bruening, J.C. ; Krashes, M.J.*

Hunger-driven motivational state competition.

Neuron 92, 187-201 (2016)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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Behavioral choice is ubiquitous in the animal kingdom and is central to goal-oriented behavior. Hypothalamic Agouti-related peptide (AgRP) neurons are critical regulators of appetite. Hungry animals, bombarded by multiple sensory stimuli, are known to modify their behavior during times of caloric need, rapidly adapting to a consistently changing environment. Utilizing ARC AgRP neurons as an entry point, we analyzed the hierarchical position of hunger related to rival drive states. Employing a battery of behavioral assays, we found that hunger significantly increases its capacity to suppress competing motivational systems, such as thirst, anxiety-related behavior, innate fear, and social interactions, often only when food is accessible. Furthermore, real-time monitoring of ARC AgRP activity revealed time-locked responses to conspecific investigation in addition to food presentation, further establishing that, even at the level of ARC AgRP neurons, choices are remarkably flexible computations, integrating internal state, external factors, and anticipated yield.

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