PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Piccoli, G. ; Condliffe, S.B.* ; Bauer, M. ; Giesert, F. ; Boldt, K. ; de Astis, S.* ; Meixner, A. ; Sarioglu, H. ; Vogt Weisenhorn, D.M. ; Wurst, W. ; Gloeckner, C.J. ; Matteoli, M.* ; Sala, C.* ; Ueffing, M.

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.

J. Neurosci. 31, 2225-2237 (2011)
Verlagsversion DOI PMC
Closed
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the single most common cause of inherited Parkinson's disease. Little is known about its involvement in the pathogenesis of Parkinson's disease mainly because of the lack of knowledge about the physiological role of LRRK2. To determine the function of LRRK2, we studied the impact of short hairpin RNA-mediated silencing of LRRK2 expression in cortical neurons. Paired recording indicated that LRRK2 silencing affects evoked postsynaptic currents. Furthermore, LRRK2 silencing induces at the presynaptic site a redistribution of vesicles within the bouton, altered recycling dynamics, and increased vesicle kinetics. Accordingly, LRRK2 protein is present in the synaptosomal compartment of cortical neurons in which it interacts with several proteins involved in vesicular recycling. Our results suggest that LRRK2 modulates synaptic vesicle trafficking and distribution in neurons and in consequence participates in regulating the dynamics between vesicle pools inside the presynaptic bouton.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
7.271
1.842
123
206
Tags
PROT-CF
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter READILY RELEASABLE POOL; REPEAT KINASE 2; CLATHRIN-MEDIATED ENDOCYTOSIS; CULTURED HIPPOCAMPAL-NEURONS; SINGLE-PARTICLE TRACKING; PAIRED-PULSE DEPRESSION; MOTOR-NERVE TERMINALS; PARKINSONS-DISEASE; SHORT-TERM; NEUROTRANSMITTER RELEASE
Sprache englisch
Veröffentlichungsjahr 2011
HGF-Berichtsjahr 2011
ISSN (print) / ISBN 0270-6474
e-ISSN 1529-2401
Zeitschrift Journal of Neuroscience
Quellenangaben Band: 31, Heft: 6, Seiten: 2225-2237 Artikelnummer: , Supplement: ,
Verlag Society for Neuroscience
Begutachtungsstatus Peer reviewed
Institut(e) CF Metabolomics & Proteomics (CF-MPC)
Institute of Developmental Genetics (IDG)
POF Topic(s) 30203 - Molecular Targets and Therapies
30204 - Cell Programming and Repair
Forschungsfeld(er) Enabling and Novel Technologies
Genetics and Epidemiology
PSP-Element(e) G-505700-001
G-500500-001
G-500500-003
PubMed ID 21307259
DOI 10.1523/JNEUROSCI.3730-10.2011
Scopus ID 79951534656
Erfassungsdatum 2011-08-11
[➜Korrektur melden]