PuSH - Publikationsserver des Helmholtz Zentrums München: A minimal-invasive method for systemic bio-monitoring of the environmental pollutant phenanthrene in humans: Thermal extraction and gas chromatography - mass spectrometry from 1 µl capillary blood.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Gruber, B. ; Schneider, J. ; Föhlinger, M. ; Buters, J.T.M. ; Zimmermann, R. ; Matuschek, G.

A minimal-invasive method for systemic bio-monitoring of the environmental pollutant phenanthrene in humans: Thermal extraction and gas chromatography - mass spectrometry from 1 µl capillary blood.

J. Chromatogr. A 1487, 254-257 (2017)

DOI

PMC

Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

Abstract
Metriken
Zusatzinfos

Phenanthrene is present in numerous environmental media and serves as a model substrate for the biomonitoring of polycyclic aromatic hydrocarbon (PAH). PAH exposure studies are commonly focused on urinary metabolites, concentrations of which are dependent on absorption, biotransformation and excretion. Monitoring of unmetabolized PAHs in blood would allow more reliable exposure assessment, but requires invasive sampling and extensive sample preparation. We describe the analysis of phenanthrene in 1. μL capillary blood using thermal extraction (TE) combined with gas chromatography - mass spectrometry (GC-MS). Less invasive sampling of 1. μL capillary blood does not require the assistance of medical staff. Compared to previous studies, analysis time was improved significantly by TE due to minimization of sample preparation steps. The evaluate method was applied successfully to the monitoring of phenanthrene blood levels. This is the first report presenting the pharmacokinetics of unmetabolized PAHs in human.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

3.981

1.295