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Circulating and disseminated tumor cells: Diagnostic tools and therapeutic targets in motion.
Oncotarget 8, 1884-1912 (2017)
Enumeration of circulating tumor cells (CTCs) in peripheral blood with the gold standard CellSearchTM has proven prognostic value for tumor recurrence and progression of metastatic disease. Therefore, the further molecular characterization of isolated CTCs might have clinical relevance as liquid biopsy for therapeutic decision-making and to monitor disease progression. The direct analysis of systemic cancer appears particularly important in view of the known disparity in expression of therapeutic targets as well as epithelial-to-mesenchymal transition (EMT)-based heterogeneity between primary and systemic tumor cells, which all substantially complicate monitoring and therapeutic targeting at present. Since CTCs are the potential precursor cells of metastasis, their in-depth molecular profiling should also provide a useful resource for target discovery. The present review will discuss the use of systemically spread cancer cells as liquid biopsy and focus on potential target antigens.
Impact Factor
Scopus SNIP
Scopus
Cited By
Cited By
Altmetric
5.168
1.056
44
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
CTCs; DTCs; EpCAM; MICs; metastases
Sprache
englisch
Veröffentlichungsjahr
2017
Prepublished im Jahr
2016
HGF-Berichtsjahr
2016
ISSN (print) / ISBN
1949-2553
e-ISSN
1949-2553
Zeitschrift
OncoTarget
Quellenangaben
Band: 8,
Heft: 1,
Seiten: 1884-1912
Verlag
Impact Journals LLC
Begutachtungsstatus
Peer reviewed
Institut(e)
Translational Metabolic Oncology (IDC-TMO)
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Radiation Sciences
PSP-Element(e)
G-521800-001
PubMed ID
27683128
Erfassungsdatum
2016-12-31