PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
von Loeffelholz, C.* ; Pfeiffer, A.F.* ; Lock, J.F.* ; Lieske, S.* ; Döcke, S.* ; Murahovschi, V.* ; Kriebel, J. ; de Las Heras Gala, T. ; Grallert, H. ; Rudovich, N.N.* ; Stockmann, M.* ; Spranger, J.* ; Jahreis, G.* ; Bornstein, S.R.* ; Lau, G.* ; Xu, A.* ; Schulz-Menger, J.* ; Exner, L.* ; Haufe, S.* ; Jordan, J.* ; Engeli, S.* ; Birkenfeld, A.L.*

ANGPTL8 (Betatrophin) is expressed in visceral adipose tissue and relates to human hepatic steatosis in two independent clinical collectives.

Horm. Metab. Res. 49, 343-349 (2017)
Postprint DOI PMC
Open Access Green
Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated.Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study. In the intervention study oral glucose testing and liver magnetic resonance scanning at baseline and after 6 months were performed. Angiopoietin-like protein 8/betatrophin mRNA was increased in visceral compared to subcutaneous adipose tissue (p<0.001). Circulating ANGPTL8/betatrophin correlated with liver steatosis (r=0.42, p=0.047), triacylglycerols (r=0.34, p=0.046), saturated (r=0.43, p=0.022), monounsaturated (r=0.51, p=0.007), and polyunsaturated fatty acids (r=-0.53, p=0.004). In the intervention study, baseline Angiopoietin-like protein 8/betatrophin correlated with age (r=0.32, p=0.010) and triacylglycerols (r=0.30, p=0.02) and was increased with hepatic steatosis (p=0.033). Weight loss reduced liver fat by 45% and circulating Angiopoietin-like protein 8/betatrophin by 11% (288±17 vs. 258±17 pg/ml; p=0.015). Angiopoietin-like protein 8/betatrophin is related to liver steatosis, while visceral adipose tissue represents an additional site of expression in humans.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
2.268
0.000
19
20
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Diabetes ; Fatty Acids ; Fatty Liver ; Hdl ; Hepatokine ; Insulin Resistance ; Ldl ; Triacylglycerides; Fatty Liver-disease; Increased Circulating Levels; Glucose-homeostasis; Insulin-resistance; Lipid-metabolism; Individuals; Serum; Angptl8/betatrophin; Association; Lipasin
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 0018-5043
e-ISSN 1439-4286
Zeitschrift Hormone and Metabolic Research
Quellenangaben Band: 49, Heft: 5, Seiten: 343-349 Artikelnummer: , Supplement: ,
Verlag Thieme
Verlagsort Stuttgart
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504091-002
G-504000-002
G-501900-402
DOI 10.1055/s-0043-102950
WOS ID WOS:000403073700004
Scopus ID 85016584181
PubMed ID 28351093
Erfassungsdatum 2017-06-19
[➜Korrektur melden]