PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Jamra, R.A.* ; Klein, K.* ; Villela, A.W.* ; Becker, T.* ; Schulze, T.G.* ; Schmael, C.* ; Deschner, M.* ; Klopp, N. ; Illig, T. ; Propping, P.* ; Cichon, S.* ; Rietschel, M.* ; Nöthen, M.M.* ; Schumacher, J.*

Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorder.

Am. J. Med. Genet. B 141B, 663-665 (2006)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Results from molecular and pharmacological studies point to involvement of the gene coding for the phosphatidylinositol-4-phosphate 5-kinase type II-alpha (PIP5K2A) in the development of schizophrenia and bipolar affective disorder (BPAD). The PIP5K2A gene locus, which is located on chromosomal region 10p12, has been implicated in the development of both disorders by independent linkage and association studies. On a cellular level, PIP5K2A is an enzyme component of the metabolism of inositol phosphate, which has been considered a potential target for the therapeutic action of lithium in BPAD patients. Given that the PIP5K2A gene is a promising candidate for the development of both disorders, we performed an association study between genetic variants at the PIP5K2A locus and 268 patients with schizophrenia, 260 patients with BPAD and 325 ethnically matched healthy controls. We failed to detect association to either disorder using PIP5K2A gene variants through single-marker and haplotype analysis. Therefore, our data does not support an involvement of the PIP5K2A locus in the etiology of either schizophrenia or BPAD in the German population. © 2006 Wiley-Liss, Inc.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
3.521
0.000
3
13
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter German; case-control; 10p12; phosphatidylinositol-4-phosphate 5-kinase type II-alpha
Sprache englisch
Veröffentlichungsjahr 2006
HGF-Berichtsjahr 2006
ISSN (print) / ISBN 1552-4841
e-ISSN 0148-7299
Zeitschrift American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Quellenangaben Band: 141B, Heft: 6, Seiten: 663-665 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken, NJ
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-003
DOI 10.1002/ajmg.b.30358
Scopus ID 33748933549
Erfassungsdatum 2006-12-31
[➜Korrektur melden]