PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Herder, C.* ; de Las Heras Gala, T. ; Carstensen-Kirberg, M.* ; Huth, C. ; Zierer, A. ; Wahl, S. ; Sudduth-Klinger, J.* ; Kuulasmaa, K.A. ; Peretz, D.* ; Ligthart, S. ; Bongaerts, B.W.C.* ; Dehghan, A.* ; Ikram, M.A. ; Jula, A.* ; Kee, F.* ; Pietilä, A.* ; Saarela, O.* ; Zeller, T.* ; Blankenberg, S.* ; Meisinger, C. ; Peters, A. ; Roden, M.* ; Salomaa, V.* ; Koenig, W.* ; Thorand, B.

Circulating levels of interleukin 1-receptor antagonist and risk of  cardiovascular disease: Meta-analysis of six population-based cohorts.

Arterioscler. Thromb. Vasc. Biol. 37, 1222-1227 (2017)
Verlagsversion Forschungsdaten DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
OBJECTIVE: Interleukin (IL)-1β represents a key cytokine in the development of cardiovascular disease (CVD). IL-1β is counter-regulated by IL-1 receptor antagonist (IL-1RA), an endogenous inhibitor. This study aimed to identify population-based studies on circulating IL-1RA and incident CVD in a systematic review, estimate the association between IL-1RA and incident CVD in a meta-analysis, and to test whether the association between IL-1RA and incident CVD is explained by other inflammation-related biomarkers in the MONICA/KORA Augsburg case-cohort study (Multinational Monitoring of Trends and Determinants in Cardiovascular Disease/Cooperative Health Research in the Region of Augsburg). APPROACH AND RESULTS: We performed a systematic literature search and identified 5 cohort studies on IL-1RA and incident CVD in addition to the MONICA/KORA Augsburg case-cohort study for a meta-analysis based on a total of 1855 CVD cases and 18 745 noncases with follow-up times between 5 and 16 years. The pooled standardized hazard ratio (95% confidence interval) for incident CVD was 1.11 (1.06-1.17) after adjustment for age, sex, anthropometric, metabolic, and lifestyle factors (P<0.0001). There was no heterogeneity in effect sizes (I(2)=0%; P=0.88). More detailed analyses in the MONICA/KORA study showed that the excess risk for CVD was attenuated by ≥10% after additional separate adjustment for serum levels of high-sensitivity C-reactive protein, IL-6, myeloperoxidase, soluble E-selectin, or soluble intercellular adhesion molecule-1. CONCLUSIONS: Serum IL-1RA levels were positively associated with risk of CVD after adjustment for multiple confounders in a meta-analysis of 6 population-based cohorts. This association may at least partially reflect a response to triggers inducing subclinical inflammation, oxidative stress, and endothelial activation.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
6.607
1.608
51
63
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Biomarker ; Cardiovascular Disease ; Cohort Study ; Inflammation ; Interleukin-1 Receptor Antagonist ; Meta-analysis
Sprache
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 1079-5642
e-ISSN 1524-4636
Zeitschrift Arteriosclerosis, Thrombosis, and Vascular Biology
Quellenangaben Band: 37, Heft: 6, Seiten: 1222-1227 Artikelnummer: , Supplement: ,
Verlag Lippincott Williams & Wilkins
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
90000 - German Center for Diabetes Research
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-504000-002
G-504000-006
G-504091-002
G-501900-401
G-504090-001
DOI 10.1161/ATVBAHA.117.309307
WOS ID WOS:000401947700028
Scopus ID 85017903827
PubMed ID 28428221
Erfassungsdatum 2017-06-14
[➜Korrektur melden]