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Assessing systems properties of yeast mitochondria through an interaction map of the organelle.
PLoS Genet. 2, 1612-1624:e170 (2006)
Mitochondria carry out specialized functions; compartmentalized, yet integrated into the metabolic and signaling processes of the cell. Although many mitochondrial proteins have been identified, understanding their functional interrelationships has been a challenge. Here we construct a comprehensive network of the mitochondrial system. We integrated genome-wide datasets to generate an accurate and inclusive mitochondrial parts list. Together with benchmarked measures of protein interactions, a network of mitochondria was constructed in their cellular context, including extra-mitochondrial proteins. This network also integrates data from different organisms to expand the known mitochondrial biology beyond the information in the existing databases. Our network brings together annotated and predicted functions into a single framework. This enabled, for the entire system, a survey of mutant phenotypes, gene regulation, evolution, and disease susceptibility. Furthermore, we experimentally validated the localization of several candidate proteins and derived novel functional contexts for hundreds of uncharacterized proteins. Our network thus advances the understanding of the mitochondrial system in yeast and identifies properties of genes underlying human mitochondrial disorders.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
0.200
0.000
60
61
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
PROTEIN-PROTEIN INTERACTIONS; SACCHAROMYCES-CEREVISIAE; CYTOCHROME-C; COPPER DETOXIFICATION; INTEGRATIVE GENOMICS; MASS-SPECTROMETRY; DISEASE GENES; EXPRESSION; NETWORKS; IDENTIFICATION
Sprache
englisch
Veröffentlichungsjahr
2006
HGF-Berichtsjahr
0
ISSN (print) / ISBN
1553-7390
e-ISSN
1553-7404
Zeitschrift
PLoS Genetics
Quellenangaben
Band: 2,
Heft: 10,
Seiten: 1612-1624,
Artikelnummer: e170
Verlag
Public Library of Science (PLoS)
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Human Genetics (IHG)
POF Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-500700-001
PubMed ID
17054397
WOS ID
WOS:000241922200011
Scopus ID
33750491220
Erfassungsdatum
2006-12-31