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Skaaby, T.* ; Taylor, A.E.* ; Jacobsen, R.K.* ; Paternoster, L.* ; Thuesen, B.H.* ; Ahluwalia, T.S.* ; Larsen, S.C.* ; Zhou, A.* ; Wong, A.* ; Gabrielsen, M.E.* ; Bjørngaard, J.H.* ; Flexeder, C. ; Männistö, S.* ; Hardy, R.* ; Kuh, D.* ; Barry, S.J.* ; Tang Møllehave, L.* ; Cerqueira, C.* ; Friedrich, N.* ; Bonten, T.N.* ; Noordam, R.* ; Mook-Kanamori, D.O.* ; Taube, C.* ; Jessen, L.E.* ; McConnachie, A.* ; Sattar, N.* ; Upton, M.N.* ; McSharry, C.* ; Bønnelykke, K.* ; Bisgaard, H.* ; Schulz, H. ; Strauch, K. ; Meitinger, T. ; Peters, A. ; Grallert, H. ; Nohr, E.A.* ; Kivimaki, M.* ; Kumari, M.* ; Völker, U.* ; Nauck, M.* ; Völzke, H.* ; Power, C.* ; Hyppönen, E.* ; Hansen, T.* ; Jørgensen, T.* ; Pedersen, O.* ; Salomaa, V.* ; Grarup, N.* ; Langhammer, A.* ; Romundstad, P.R.* ; Skorpen, F.* ; Kaprio, J.* ; R Munafò, M.* ; Linneberg, A.*

Investigating the causal effect of smoking on hay fever and asthma: A Mendelian randomization meta-analysis in the CARTA consortium.

Sci. Rep. 7:2224 (2017)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic variants as markers of exposures to examine causal effects. We examined the causal effect of smoking on hay fever and asthma by using the smoking-associated single nucleotide polymorphism (SNP) rs16969968/rs1051730. We included 231,020 participants from 22 population-based studies. Observational analyses showed that current vs never smokers had lower risk of hay fever (odds ratio (OR) = 0·68, 95% confidence interval (CI): 0·61, 0·76; P < 0·001) and allergic sensitization (OR = 0·74, 95% CI: 0·64, 0·86; P < 0·001), but similar asthma risk (OR = 1·00, 95% CI: 0·91, 1·09; P = 0·967). Mendelian randomization analyses in current smokers showed a slightly lower risk of hay fever (OR = 0·958, 95% CI: 0·920, 0·998; P = 0·041), a lower risk of allergic sensitization (OR = 0·92, 95% CI: 0·84, 1·02; P = 0·117), but higher risk of asthma (OR = 1·06, 95% CI: 1·01, 1·11; P = 0·020) per smoking-increasing allele. Our results suggest that smoking may be causally related to a higher risk of asthma and a slightly lower risk of hay fever. However, the adverse events associated with smoking limit its clinical significance.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Zeitschrift Scientific Reports
Quellenangaben Band: 7, Heft: 1, Seiten: , Artikelnummer: 2224 Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Genetic Epidemiology (IGE)
Institute of Human Genetics (IHG)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
80000 - German Center for Lung Research
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-003
G-504100-001
G-500700-001
G-504000-006
G-504091-002
G-501800-391
PubMed ID 28533558
DOI 10.1038/s41598-017-01977-w
WOS ID WOS:000401754200011
Scopus ID 85019722877
Erfassungsdatum 2017-06-14
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