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Guthoff, M. ; Wagner, R. ; Vosseler, D.* ; Peter, A. ; Nadalin, S.* ; Häring, H.-U. ; Fritsche, A. ; Heyne, N.

Impact of end-stage renal disease on glucose metabolism-a matched cohort analysis.

Nephrol. Dial. Transplant. 32, 670-676 (2017)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Background. Renal function is known to affect glucose metabolism. The aim of this study was to assess glucose metabolism in end-stage renal disease (ESRD) patients and in matched controls with normal renal function and to delineate its underlying pathophysiology. Methods. ESRD patients without diabetes mellitus on the active kidney transplant waiting list of a large European university hospital were metabolically phenotyped by an oral glucose tolerance test (OGTT) and by calculating insulin sensitivity and secretion indices. Matched controls with normal renal function were derived from the TUEF (Tuebingen Family) study cohort, which includes healthy non-diabetic individuals with an increased risk of developing type 2 diabetes. Matches were made for (i) gender, age and body mass index (BMI) (cohort 1) and for (ii) gender, age, BMI, fasting plasma glucose (FPG) and 2-h glucose in OGTT (cohort 2). Results. A total of 107 patients ( 90 on haemodialysis and 17 on peritoneal dialysis) and two cohorts, each comprising 107 matched controls, were investigated. ESRD patients had significantly lower FPG. Additional matching for OGTT glucose concentrations revealed significantly lower insulin sensitivity in ESRD patients than in controls. This finding was abrogated after adjustment for triglyceride levels. Insulin secretion, however, was significantly higher in ESRD patients. Insulin kinetics during OGTT as well as C-peptide levels demonstrate higher insulin secretion to be a compensation for lower insulin sensitivity and not to result from impaired insulin clearance. Conclusion. Our study is the first to provide metabolic phenotyping in patients with ESRD and to compare them with matched controls with normal renal function. Glucose metabolism differs substantially between cohorts, with insulin resistance and a compensatory increase in insulin secretion in ESRD patients.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dialysis ; End-stage Renal Disease ; Glucose Metabolism ; Insulin Resistance ; Insulin Secretion; Chronic Kidney-disease; Assessing Insulin Sensitivity; Chronic-hemodialysis Patients; Lipoprotein Metabolism; Cardiovascular-disease; Model Assessment; Resistance; Indexes; Homeostasis; Secretion
Sprache
Veröffentlichungsjahr 2017
HGF-Berichtsjahr 2017
ISSN (print) / ISBN 0931-0509
e-ISSN 1460-2385
Zeitschrift Nephrology Dialysis Transplantation
Quellenangaben Band: 32, Heft: 4, Seiten: 670-676 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF Topic(s) 90000 - German Center for Diabetes Research
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502400-001
DOI 10.1093/ndt/gfx018
WOS ID WOS:000401057000014
Scopus ID 85019114337
PubMed ID 28407130
Erfassungsdatum 2017-06-21
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