PuSH - Publikationsserver des Helmholtz Zentrums München: Independent and opposite associations of serum levels of omentin-1 and adiponectin with increases of glycaemia and incident type 2 diabetes in an older population: KORA F4/FF4 Study.

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Herder, C.* ; Kannenberg, J.M.* ; Niersmann, C.* ; Huth, C. ; Carstensen-Kirberg, M.* ; Wittenbecher, C.* ; Schulze, M.B.* ; Blüher, M.* ; Rathmann, W.G.* ; Peters, A. ; Roden, M.* ; Meisinger, C. ; Thorand, B.

Independent and opposite associations of serum levels of omentin-1 and adiponectin with increases of glycaemia and incident type 2 diabetes in an older population: KORA F4/FF4 Study.

Eur. J. Endocrinol. 177, 277-286 (2017)

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OBJECTIVE: Cross-sectional studies found that higher levels of the novel adipokine omentin-1 were associated with higher adiponectin and lower levels of risk factors for type 2 diabetes, but its relevance for incident type 2 diabetes is currently not understood. Therefore, this study investigated whether serum omentin-1 was associated with changes in glycaemia and incident type 2 diabetes independently of adiponectin. DESIGN AND METHODS: The study was based on participants aged 62-81 years from the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4/FF4 cohort. Associations of baseline serum levels of omentin-1 and adiponectin with changes in glycaemia were assessed in 471 non-diabetic participants, associations between both adipokines and incident type 2 diabetes in 76 cases and 430 non-cases (follow-up time 6.5 years). Multivariable linear and logistic regression models were adjusted for multiple potential confounders. RESULTS: Higher serum levels of omentin-1 were associated with increases in fasting glucose, 2-hour glucose and HbA1c (all P<0.001) and with incident type 2 diabetes (adjusted OR (95% CI) 1.40 (1.03; 1.90) per SD of log2-transformed omentin-1; P=0.032). These associations were independent from adiponectin levels, which showed associations with changes in glycaemia and risk of type 2 diabetes in the opposite direction. We found no statistically significant interactions of omentin-1 with adiponectin or sex in the association with incident type 2 diabetes (all P>0.1). CONCLUSIONS: Systemic levels of omentin-1 were positively associated with increases in glycaemia and incident type 2 diabetes in this older population. These associations were independent of potential confounders including adiponectin.

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