PuSH - Publikationsserver des Helmholtz Zentrums München: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Informationen

Hinweise zu Qualitätskriterien von Zeitschriften

Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016

CC Licencences

Metriken für Publikationen

Navigation

Startseite

English

EVA: Veröffentlichen

Neuer EVA Antrag

Recherche

Erweiterte Suche

Durchblättern nach ...

... HMGU-Autoren/Konsortien

... Organisationsstruktur

... Zeitschriften

... Publikationstypen

... Forschungsdaten

... Arbeitsgruppen

... Erscheinungsjahr

Publikationen im Überblick

Statistik

HGF Fortschrittsbericht

OA Publikationen

Eintragen

Neue Publikation eintragen

Neue Publikation holen aus...

...EVA

Fehlende Publikation melden

Highlights

Suche

Hilfe & Kontakt

Ansprechpartner

Hilfe

Datenschutz

Helmholtz Open Science

Bibliometrische Indikatoren

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Zillikens, M.C.* ; Demissie, S.* ; Hsu, Y.H.* ; Yerges-Armstrong, L.M.* ; Chou, W.C.* ; Stolk, L.* ; Livshits, G.* ; Broer, L.* ; Johnson, T.* ; Koller, D.L.* ; Kutalik, Z.* ; Luan, J.* ; Malkin, I.* ; Ried, J.S. ; Smith, A.V.* ; Thorleifsson, G.* ; Vandenput, L.* ; Hua Zhao, J.* ; Zhang, W.* ; Aghdassi, A.* ; Åkesson, K.* ; Amin, N.* ; Baier, L.J.* ; Barroso, I.* ; Bennett, D.A.* ; Bertram, L.* ; Biffar, R.* ; Bochud, M.* ; Boehnke, M.* ; Borecki, I.B.* ; Buchman, A.S.* ; Byberg, L.* ; Campbell, H.* ; Campos Obanda, N.* ; Cauley, J.A.* ; Cawthon, P.M.* ; Cederberg, H.* ; Chen, Z.* ; Cho, N.H.* ; Jin Choi, H.* ; Claussnitzer, M.* ; Collins, F.C.* ; Cummings, S.R.* ; de Jager, P.L.* ; Demuth, I.* ; Dhonukshe-Rutten, R.A.M.* ; Diatchenko, L.* ; Eiriksdottir, G.* ; Enneman, A.W.* ; Erdos, M.R.* ; Eriksson, J.G.* ; Eriksson, J.* ; Estrada, K.* ; Evans, D.S.* ; Feitosa, M.F.* ; Fu, M.* ; Garcia, M.* ; Gieger, C. ; Girke, T.* ; Glazer, N.L.* ; Grallert, H. ; Grewal, J.* ; Han, B.G.* ; Hanson, R.L.* ; Hayward, C.* ; Hofman, A.* ; Hoffman, E.P.* ; Homuth, G.* ; Hsueh, W.C.* ; Hubal, M.J.* ; Hubbard, A.* ; Huffman, K.M.* ; Husted, L.B.* ; Illig, T. ; Ingelsson, E.* ; Ittermann, T.* ; Jansson, J.O.* ; Jordan, J.M.* ; Jula, A.* ; Karlsson, M.* ; Khaw, K.T.* ; Kilpeläinen, T.O.* ; Klopp, N. ; Kloth, J.S.L.* ; Koistinen, H.A.* ; Kraus, W.E.* ; Kritchevsky, S.B.* ; Kuulasmaa, T.* ; Kuusisto, J.* ; Laakso, M.* ; Lahti, J.* ; Lang, T.* ; Langdahl, B.L.* ; Launer, L.J.* ; Lee, J.Y.* ; Lerch, M.M.* ; Lewis, J.R.* ; Lind, L.* ; Lindgren, C.* ; Liu, Y.* ; Liu, T.* ; Ljunggren, O.* ; Lorentzon, M.* ; Luben, R.N.* ; Maixner, W.* ; McGuigan, F.E.* ; Medina-Gomez, C.* ; Meitinger, T. ; Melhus, H.* ; Mellström, D.* ; Melov, S.* ; Michaëlsson, K.* ; Mitchell, B.D.* ; Morris, A.P.* ; Mosekilde, L.* ; Newman, A.* ; Nielson, C.M.* ; O'Connell, J.R.* ; Oostra, B.A.* ; Orwoll, E.S.* ; Palotie, A.* ; Parker, S.C.* ; Peacock, M.* ; Perola, M.* ; Peters, A. ; Polasek, O.* ; Prince, R.L.* ; Räikkönen, K.* ; Ralston, S.H.* ; Ripatti, S.* ; Robbins, J.A.* ; Rotter, J.I.* ; Rudan, I.* ; Salomaa, V.* ; Satterfield, S.* ; Schadt, E.E.* ; Schipf, S.* ; Scott, L.J.* ; Sehmi, J.* ; Shen, J.* ; Soo Shin, C.* ; Sigurdsson, G.* ; Smith, S.* ; Soranzo, N.* ; Stancáková, A.* ; Steinhagen-Thiessen, E.* ; Streeten, E.A.* ; Styrkarsdottir, U.* ; Swart, K.M.A.* ; Tan, S.T.* ; Tarnopolsky, M.A.* ; Thompson, P.J.* ; Thomson, C.A.* ; Thorsteinsdottir, U.* ; Tikkanen, E.* ; Tranah, G.J.* ; Tuomilehto, J.* ; van Schoor, N.M.* ; Verma, A.* ; Vollenweider, P.* ; Völzke, H.* ; Wactawski-Wende, J.* ; Walker, M.* ; Weedon, M.N.* ; Welch, R.* ; Wichmann, H.-E. ; Widen, E.* ; Williams, F.M.K.* ; Wilson, J.F.* ; Wright, N.C.* ; Xie, W.* ; Yu, L.* ; Zhou, Y.* ; Chambers, J.C.* ; Döring, A. ; van Duijn, C.M.* ; Econs, M.J.* ; Gudnason, V.* ; Kooner, J.S.* ; Psaty, B.M.* ; Spector, T.D.* ; Stefansson, K.* ; Rivadeneira, F.* ; Uitterlinden, A.G.* ; Wareham, N.J.* ; Ossowski, V.* ; Waterworth, D.* ; Loos, R.J.F.* ; Karasik, D.* ; Harris, T.B.* ; Ohlsson, C.* ; Kiel, D.P.*

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Nat. Commun. 8:80 (2017)

Verlagsversion

Forschungsdaten

DOI

PMC

	Open Access Gold

Abstract
Metriken
Zusatzinfos

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10(-8)) or suggestively genome wide (p < 2.3 × 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

12.124

2.995

100